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p(HGNC:P2RX7)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
P2RX7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

The role of inflammasome in Alzheimer’s disease v1.0.3

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 4

a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) View Subject | View Object

In addition, Brilliant Blue G (BBG), a P2X7 receptor antagonist, inhibits ATP-induced activation of the NLRP2 inflammasome in human astrocytes (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium

composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) hasComponent p(HGNC:P2RX7) View Subject | View Object

Appears in Networks:

a(MESH:Microglia) increases p(HGNC:P2RX7) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

Out-Edges 7

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

A subsequent study demonstrated that P2X7 purinergic receptor is involved in the activation of NLRP1 inflammasome (Silverman et al., 2009) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Similarly, the P2X7 purinergic receptor has been shown to activate the NLRP1 inflammasome in primary neurons (Silverman et al., 2009) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.