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Activation and regulation of the inflammasomes 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:49.734836
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
124
Number Edges
185
Number Components
6
Network Density
0.0121295567794388
Average Degree
1.49193548387097
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2 33%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 30%
The role of inflammasome in Alzheimer’s disease v1.0.3 26%
Anatabine ameliorates experimental autoimmune thyroiditis. v1.0.0 20%
In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0 20%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 15%
Alpha-synuclein oligomers: a new hope v1.0.0 12%
Heme Curation v0.0.1-dev 12%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 12%
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1 12%

Sample Edges

p(HGNC:EIF2S1) hasVariant p(HGNC:EIF2S1, pmod(Ph)) View Subject | View Object

complex(p(HGNC:APAF1), p(HGNC:CYCS)) hasComponent p(HGNC:APAF1) View Subject | View Object

complex(p(HGNC:APAF1), p(HGNC:CYCS)) hasComponent p(HGNC:CYCS) View Subject | View Object

a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) View Subject | View Object

RIG-I is widely known as a PRR that senses RNA and that signals via mitochondrial antiviral signalling protein (MAVS) to induce an interferon (IFN) response2, and IFI16 has been suggested to be a DNA sensor that signals via the protein STING (stimulator of IFN genes; also known as TMEM173) to generate an IFN response23. PubMed:23702978

Annotations
Confidence
High
NeuroMMSigDB
Interferon signaling subgraph

a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") View Subject | View Object

One checkpoint is that bacterial mRNA from live bacteria (also known as vita-PAMPs)44 activates NLRP3; the other checkpoint is that TLR4- and TRIF (TIR domain-containing adaptor protein inducing IFNβ)-dependent signalling — which is triggered by bacterial lipopolysaccharide (LPS) — mediate the secretion of type I IFNs, inducing pro-caspase 11 expression and activation by triggering the IFNα/β receptor (IFNAR) (FIG. 1). PubMed:23702978

Annotations
Confidence
Medium
NeuroMMSigDB
Interferon signaling subgraph

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:"inflammatory response")

In-Edges: 55 | Out-Edges: 24 | Explore Neighborhood | Download JSON

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

path(MESH:"Neurodegenerative Diseases")

In-Edges: 24 | Out-Edges: 19 | Children: 3 | Explore Neighborhood | Download JSON

bp(GO:"apoptotic process")

In-Edges: 94 | Out-Edges: 13 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.