The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0||50%|
|Tau Modifications v1.9.5||33%|
|Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0||30%|
|Activation and regulation of the inflammasomes v1.0.0||30%|
|Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2||29%|
|Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0||28%|
|The role of inflammasome in Alzheimer’s disease v1.0.3||26%|
|Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0||25%|
|Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0||25%|
|Alzheimer’s disease and the autophagic-lysosomal system v1.0.0||24%|
In AD, microglial cells and astrocytes express NLRP3, which in turn can detect A beta plaques and act by secreting caspase-1 to activate IL-1 beta and IL- 18 [23–25].
It is noteworthy that IL-1 beta and IL-18 can activate various cell types, par- ticularly astrocytes and microglia to induce additional cytokine release involving IL-1 beta , IL-6, and IL-18, and also nitric oxide (NO) synthase that can stimulate production of free radical NO, leading to the forma- tion of peroxynitrite that denatures DNA and impairs cellular energy pathways [48, 49].
NO can also bring about apoptosis of hippocampal neurons via caspase- 3 activity  whereas astrocyte-secreted IL-1 beta can increase the production of APP and A beta from neu- rons [51–53] (Fig. 1).
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.