a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex"))

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PubMed:24561250

In vivo and cell studies demonstrate that fibrillar Aβ activates the NLRP3 inflammasome which is composed of the NLRP3 receptor, ASC and caspase-1, to produce IL-1β in microglia (Halle et al., 2008)

Related Edges 1

• complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B)

Cell Ontology (CL)

microglial cell

Confidence

Medium

NeuroMMSigDB

Amyloidogenic subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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