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Appears in Networks 2

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a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) View Subject | View Object

RIG-I is widely known as a PRR that senses RNA and that signals via mitochondrial antiviral signalling protein (MAVS) to induce an interferon (IFN) response2, and IFI16 has been suggested to be a DNA sensor that signals via the protein STING (stimulator of IFN genes; also known as TMEM173) to generate an IFN response23. PubMed:23702978

a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Of these, the NLRP3 inflammasome can be acti- vated via bacterial RNA species [3]. PubMed:27314526


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.