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a(CHEBI:"RNA fragment")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
RNA fragment
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 0

Out-Edges 2

a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) View Subject | View Object

RIG-I is widely known as a PRR that senses RNA and that signals via mitochondrial antiviral signalling protein (MAVS) to induce an interferon (IFN) response2, and IFI16 has been suggested to be a DNA sensor that signals via the protein STING (stimulator of IFN genes; also known as TMEM173) to generate an IFN response23. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interferon signaling subgraph

a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Of these, the NLRP3 inflammasome can be acti- vated via bacterial RNA species [3]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.