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  3. complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD))

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD))

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Components

Appears in Networks 1

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 0

Out-Edges 4

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) hasComponent p(HGNC:CASP1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) hasComponent p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

As for the NLRP1 and NLRP3 inflammasomes, the oligomerzied NLRs recruit and interact with the adaptor protein ASC, which in turn recruits the effector protein procaspase-1 that is central to the activation of inflammasomes (Huang et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.