1. Catalog
  2. Nodes
  3. a(CHEBI:paraquat)

a(CHEBI:paraquat)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
paraquat
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

In-Edges 3

composite(a(CHEBI:paraquat), a(HBP:HBP00053)) hasComponent a(CHEBI:paraquat) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) hasComponent a(CHEBI:paraquat) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) hasComponent a(CHEBI:paraquat) View Subject | View Object

Appears in Networks:

Out-Edges 4

a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") View Subject | View Object

Cells expressing WT tau behave as control cells and display a dose-dependent increase in CMA activity upon exposure to paraquat (Fig. 3f) or thapsigargin (Fig. 3g) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Intracellular Space
Confidence
High
MeSH
Brain

a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Caspase subgraph

a(CHEBI:paraquat) increases p(HGNC:CASP1) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Caspase subgraph

a(CHEBI:paraquat) increases p(HGNC:IL1B) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.