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Toll like receptor subgraph

Name
Toll like receptor subgraph
Namespace Keyword
Subgraph
Namespace
NeuroMMSigDB
Namespace Version
1.0.3
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno

Sample Annotated Edges 5

a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

NLRP3 inflammasome activation results from TLR ligation and concomitant uptake of Ab in models of AD PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Toll like receptor subgraph

p(HGNC:BIRC2) decreases complex(GO:ripoptosome) View Subject | View Object

The ripoptosome contains caspase 8, FAS-associated death domain protein (FADD) and receptor-interacting protein 1 (RIP1; also known as RIPK1), and forms spontaneously in response to loss or inhibition of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP), inhibitor of apoptosis protein 1 (IAP1; also known as BIRC3) and IAP2 (also known as BIRC2) (REF 56). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Toll like receptor subgraph

p(HGNC:BIRC3) decreases complex(GO:ripoptosome) View Subject | View Object

The ripoptosome contains caspase 8, FAS-associated death domain protein (FADD) and receptor-interacting protein 1 (RIP1; also known as RIPK1), and forms spontaneously in response to loss or inhibition of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP), inhibitor of apoptosis protein 1 (IAP1; also known as BIRC3) and IAP2 (also known as BIRC2) (REF 56). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Toll like receptor subgraph

p(HGNC:XIAP) decreases complex(GO:ripoptosome) View Subject | View Object

The ripoptosome contains caspase 8, FAS-associated death domain protein (FADD) and receptor-interacting protein 1 (RIP1; also known as RIPK1), and forms spontaneously in response to loss or inhibition of the antiapoptotic proteins X-linked inhibitor of apoptosis protein (XIAP), inhibitor of apoptosis protein 1 (IAP1; also known as BIRC3) and IAP2 (also known as BIRC2) (REF 56). PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Toll like receptor subgraph

a(MESH:Astrocytes) increases p(HGNC:TLR4) View Subject | View Object

Pattern recognition receptors such as the TLR4 receptor are expressed in the brain’s own immune cells like microglia and astrocytes that induce inflammation via cytokine secretion [38]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

Showing 5 of 8 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.