1. Catalog
  2. Nodes
  3. p(HGNC:PYCARD)

p(HGNC:PYCARD)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PYCARD
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 15

complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space
NeuroMMSigDB
Caspase subgraph

complex(GO:"inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP3 inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP1 inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) View Subject | View Object

They include the adaptor protein, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), which is an essential component of the NLRP1, NLRP2 and NLRP3 inflammasomes, but not of the more complex NLRC4 inflammasome (Martinon et al., 2009; Minkiewicz et al., 2013; Schroder and Tschopp, 2010) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) View Subject | View Object

ATP, a danger-associated molecular pattern that is released from damaged cells after brain injury, activates the NLRP2 inflammasome, which consists of the NLRP2 receptor, ASC and caspase-1, in human astrocytes (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

Out-Edges 9

p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) View Subject | View Object

Using its CARD, ASC brings monomers of procaspase 1 into close proximity, which initiates caspase 1 self- cleavage and the formation of the active heterotetrameric caspase 1. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) View Subject | View Object

They include the adaptor protein, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), which is an essential component of the NLRP1, NLRP2 and NLRP3 inflammasomes, but not of the more complex NLRC4 inflammasome (Martinon et al., 2009; Minkiewicz et al., 2013; Schroder and Tschopp, 2010) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) View Subject | View Object

ATP, a danger-associated molecular pattern that is released from damaged cells after brain injury, activates the NLRP2 inflammasome, which consists of the NLRP2 receptor, ASC and caspase-1, in human astrocytes (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Under certain but not all conditions ASC (Martinon et al., 2009) or Naip5 (NLR family, apoptosis inhibitory protein 5) (Lightfield et al., 2011) is required for the activity of the NLRC4 inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

The adaptor protein ASC is important for the activation of NLRC4 inflammasome in astrocytes, while Naip 5 is not (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
High
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) View Subject | View Object

Recently we identify that palmitate activates the NLRC4 inflammasome in primary astrocytes to release IL-1β, and ASC participates in the activation of the NLRC4 inflammasome (Liu and Chan, 2014) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

p(HGNC:PYCARD) increases p(HGNC:IL18) View Subject | View Object

ASC neutralization reduces the upregulation in IL-18 and IL-1β levels (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:PYCARD) increases p(HGNC:IL1B) View Subject | View Object

ASC neutralization reduces the upregulation in IL-18 and IL-1β levels (de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, NLRC4 and ASC levels are upregulated in the brains of AD patients (Liu and Chan, 2014), suggesting a possible role of the NLRC4 inflammasome in AD pathogenesis PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.