a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex"))

View Subject View Object

PubMed:28019679

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation

Related Edges 4

• a(CHEBI:paraquat) increases p(HGNC:CASP1)
• a(CHEBI:paraquat) increases p(HGNC:IL1B)
• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)
• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1)

Confidence

High

MeSH

Neurons

NeuroMMSigDB

Caspase subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---