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PubMed: 27314526

Title
Inflammasome Involvement in Alzheimer's Disease.
Journal
Journal of Alzheimer's disease : JAD
Volume
54
Issue
None
Pages
45-53
Date
2016-06-15
Authors
Olsen I | Singhrao SK

Evidence 6cdcca2502
JSON

Of these, the NLRP3 inflammasome can be acti- vated via bacterial RNA species [3].

a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

Evidence 6f1d819560
JSON

In AD, microglial cells and astrocytes express NLRP3, which in turn can detect A beta plaques and act by secreting caspase-1 to activate IL-1 beta and IL- 18 [23–25].

a(CHEBI:"amyloid-beta") association p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

a(MESH:Astrocytes) increases p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

a(MESH:Microglia) increases p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Evidence f64c854bc0
JSON

It is noteworthy that IL-1 beta and IL-18 can activate various cell types, par- ticularly astrocytes and microglia to induce additional cytokine release involving IL-1 beta , IL-6, and IL-18, and also nitric oxide (NO) synthase that can stimulate production of free radical NO, leading to the forma- tion of peroxynitrite that denatures DNA and impairs cellular energy pathways [48, 49].

a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

p(HGNC:IL18) increases bp(GO:"microglial cell activation") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

p(HGNC:IL18) increases bp(GO:"astrocyte activation") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

p(HGNC:IL1B) increases bp(GO:"microglial cell activation") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

p(HGNC:IL1B) increases bp(GO:"astrocyte activation") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

Evidence 334f04e003
JSON

NO can also bring about apoptosis of hippocampal neurons via caspase- 3 activity [50] whereas astrocyte-secreted IL-1 beta can increase the production of APP and A beta from neu- rons [51–53] (Fig. 1).

a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

act(p(HGNC:CASP3)) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

sec(p(HGNC:IL1B)) increases p(HGNC:APP) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

Evidence 5cfe1d7a78
JSON

Additionally, it can induce phosphorylation of the tau protein and promote for- mation of neurofibrillary tangles through the mitogen activated protein kinases-p38 (MAPK-p38) stress pathway [22, 54].

a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
MAPK-JNK subgraph
NeuroMMSigDB
Nitric oxide subgraph
NeuroMMSigDB
Tau protein subgraph

a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
MAPK-JNK subgraph
NeuroMMSigDB
Nitric oxide subgraph
NeuroMMSigDB
Tau protein subgraph

bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
MAPK-JNK subgraph
NeuroMMSigDB
Nitric oxide subgraph
NeuroMMSigDB
Tau protein subgraph

Evidence ea96651f0d
JSON

Pattern recognition receptors such as the TLR4 receptor are expressed in the brain’s own immune cells like microglia and astrocytes that induce inflammation via cytokine secretion [38].

a(MESH:Astrocytes) increases p(HGNC:TLR4) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

a(MESH:Microglia) increases p(HGNC:TLR4) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

p(HGNC:TLR4) increases bp(GO:"cytokine secretion") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

Evidence b465753ed9
JSON

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation.

sec(a(MESH:Interleukins)) association path(MESH:Dementia) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) association sec(a(MESH:Interleukins)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

Evidence fe53494fb9
JSON

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35].

a(MESH:Microglia) increases p(HGNC:P2RX7) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

Evidence 5b0187ced8
JSON

The NLRP3 inflammasome has a role in AD by increas- ing caspase-1 expression levels in AD brains [13, 23].

complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

Evidence 00766c087d
JSON

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis.

complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

Evidence 02fa5f5136
JSON

They appear to be involved in several pathological processes activated by microbes including Alzheimer’s disease (AD).

complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High

path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High

Evidence 334d1ae070
JSON

Post activation of the inflammasome, caspase 1 enzyme initiates the maturation of pro-inflammatory cytokines particularly interleukin (IL)-1beta, IL-18, and IL-33 [4] (Fig. 1),and inflammation mediated cell death occurs via the nucleotide-binding domain and leucine-rich repeat(NLR) family of proteins [5].

act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Evidence db965ce378
JSON

Both IL-1 beta and IL-18 are generated in their mature secreted form by caspase-1 through activa- tion of the inflammasome.

complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Evidence 9a17ad5639
JSON

In the NLRP3 inflammasome, the NLR pro- tein recruits the inflammasome-adaptor protein apoptosis-associated speck-like protein containing CARD (ASC), which in turn interacts with caspase- 1 leading to its activation [7].

composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

Evidence ca95eaadda
JSON

Once activated, caspase-1 promotes the maturation of the proin- flammatory cytokines IL-1 beta , IL-18, and IL-33.

act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

Evidence 3bddcbdaf7
JSON

However, IL- 18 can be derived as a byproduct from the activities of various extracellular enzymes such as protease 3, serine protease, elastase and cathepsin G [62–65].

act(p(FPLX:ELA)) increases p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:CTSG)) increases p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

act(p(HGNC:PRSS3)) increases p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

Evidence cbab821135
JSON

Pro-inflammatory IL-18 increases AD-associated A beta deposition in human neuron-like cells in culture [55]. IL-18 also increases the expression of glycogen synthase kinase 3 beta (GSK-3 beta ) and cyclin-dependent kinase 5, both of which are involved in hyperphos- phorylation of the tau protein [56].

p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Cyclin-CDK subgraph
NeuroMMSigDB
GSK3 subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tau protein subgraph

p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Cyclin-CDK subgraph
NeuroMMSigDB
GSK3 subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tau protein subgraph

p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Cyclin-CDK subgraph
NeuroMMSigDB
GSK3 subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tau protein subgraph

p(HGNC:IL18) increases p(HGNC:GSK3B) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Cyclin-CDK subgraph
NeuroMMSigDB
GSK3 subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tau protein subgraph

p(HGNC:IL18) increases p(HGNC:CDK5) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Cyclin-CDK subgraph
NeuroMMSigDB
GSK3 subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Tau protein subgraph

Evidence 4bc4f6a3c3
JSON

Increased levels of IL-1 beta and IL-18 have been detected in serum, cerebrospinal fluid, and brains of patients with AD and in other forms of dementia [42–46].

p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

Evidence c75b48fc44
JSON

Both these studies indicated an important role of IL-18 in AD.

p(HGNC:IL18) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:"Alzheimer Disease") association p(HGNC:IL18) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Interleukin signaling subgraph

Evidence ad1aadca7a
JSON

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation.

act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

Evidence 8bd7a9e617
JSON

Longitudinal studies including that by Ide et al. [8] all agree that in AD, the presence of periodonti- tis appears to be associated with a marked increase in cognitive decline.

path(MESH:Periodontitis) decreases bp(GO:cognition) View Subject | View Object

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.