a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process")

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PubMed:27314526

It is noteworthy that IL-1 beta and IL-18 can activate various cell types, par- ticularly astrocytes and microglia to induce additional cytokine release involving IL-1 beta , IL-6, and IL-18, and also nitric oxide (NO) synthase that can stimulate production of free radical NO, leading to the forma- tion of peroxynitrite that denatures DNA and impairs cellular energy pathways [48, 49].

Related Edges 15

• a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite)
• a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change")
• bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B))
• bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6))
• bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18))
• bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2))
• bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B))
• bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6))
• bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18))
• bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2))
• p(HGNC:IL18) increases bp(GO:"microglial cell activation")
• p(HGNC:IL18) increases bp(GO:"astrocyte activation")
• p(HGNC:IL1B) increases bp(GO:"microglial cell activation")
• p(HGNC:IL1B) increases bp(GO:"astrocyte activation")
• act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide")

Confidence

Medium

MeSH

Brain

MeSH

Cerebrospinal Fluid

MeSH

Serum

MeSH

Alzheimer Disease

NeuroMMSigDB

Interleukin signaling subgraph

NeuroMMSigDB

Nitric oxide subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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