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bp(GO:"cell proliferation")

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Entity

Name
cell proliferation
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

g(HGNC:TP53) decreases bp(GO:"cell proliferation") View Subject | View Object

The selective knockdown of genes such as TP53, led to a decrease in G1 length and thus an overall increase in cell proliferation (Supplementary Fig. 2d) PubMed:29686391

Appears in Networks:

act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") View Subject | View Object

P2X7 activation is followed by a number of downstream events, including release of pro-inflammatory mediators, cell death, and proliferation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Inflammatory response subgraph

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell proliferation") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"carbon monoxide") decreases bp(GO:"cell proliferation") View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"iron(2+)") increases bp(GO:"cell proliferation") View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:Trolox) decreases bp(GO:"cell proliferation") View Subject | View Object

Heme effects were shown to be redoxsensitive, since the antioxidant Trolox (100 mM) abrogated heme-induced VSMC migration and proliferation (Fig. 1C,D). PubMed:22954673

Appears in Networks:
Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:dibenziodolium) decreases bp(GO:"cell proliferation") View Subject | View Object

Moreover, DPI strongly inhibited heme-induced VSMC migration (Fig. 2B) and blunted the proliferative capability of heme-treated VSMC that reached levels below the controls. (Fig. 2C), indicating that heme effects on VSMC migration and proliferation are modulated by NADPHox. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases bp(GO:"cell proliferation") View Subject | View Object

As can be observed in Fig. 1, heme has a potent chemotactic activity on VSMC (Fig. 1A), and is also a potent inducer of VSMC proliferation (Fig. 1B). PubMed:22954673

Appears in Networks:
Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases bp(GO:"cell proliferation") View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

p(HGNC:HBB) increases bp(GO:"cell proliferation") View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

p(RGD:Mapk1) positiveCorrelation bp(GO:"cell proliferation") View Subject | View Object

Among the redox-sensitive molecules, ERK-2, a member of MAPK family, is of crucial importance to VSMC proliferation and migration [21]. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

Out-Edges 1

bp(GO:"cell proliferation") positiveCorrelation p(RGD:Mapk1) View Subject | View Object

Among the redox-sensitive molecules, ERK-2, a member of MAPK family, is of crucial importance to VSMC proliferation and migration [21]. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.