path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7)

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PubMed:27314526

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35].

Related Edges 3

• a(MESH:Microglia) increases p(HGNC:P2RX7)
• p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex"))
• p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease")

Confidence

Medium

MeSH

Alzheimer Disease

NeuroMMSigDB

Caspase subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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