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a(MESH:Astrocytes)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Astrocytes
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 6

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Alpha-synuclein oligomers: a new hope v1.0.0

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 3

a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes)) View Subject | View Object

In addition, flow cytometry analysis demonstrated that heparin reduces dye-conjugated pff uptake in both TFEB and EGFP transduced astrocytes, suggesting that macropino- cytosis is responsible for astroglial pff uptake PubMed:30108137

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte

Out-Edges 11

a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") View Subject | View Object

Of note is that in both of these catastrophic disorders, reduced nAChR activity/expression is accompanied by increased levels of kynurenic acid (KYNA), a tryptophan metabolite that in the brain is primarily produced and released by astrocytes (244, 419). PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) View Subject | View Object

Interestingly, it was very recently reported that astrocytes take up a-syn oligomers and degrade it via the lysosomal pathway, but this pathway can become saturated leading to mitochondrial fragmentation [89]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High

a(MESH:Astrocytes) increases p(MGI:Tfeb) View Subject | View Object

Transcriptomic analysis of these isolated astrocytes revealed an increase in TFEB tran- scripts, as well as transcripts of several of its well-known target genes in the rTg4510 relative to wild-type controls PubMed:30108137

Appears in Networks:

act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils") View Subject | View Object

In addition, flow cytometry analysis demonstrated that heparin reduces dye-conjugated pff uptake in both TFEB and EGFP transduced astrocytes, suggesting that macropino- cytosis is responsible for astroglial pff uptake PubMed:30108137

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte

act(a(MESH:Astrocytes)) decreases p(HGNC:APP) View Subject | View Object

Extracellular degradation of ISF proteins mainly consists of degradation by proteases expressed and secreted by cells such as astrocytes PubMed:26195256

Appears in Networks:

a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) View Subject | View Object

Specifically, ISF Aβ can be taken up by microglia and astrocytes, whereas perivascular Aβ can be degraded by vascular smooth muscle cells, perivascular macrophages, and astrocytes PubMed:26195256

Appears in Networks:

a(MESH:Astrocytes) increases p(HGNC:NLRP3) View Subject | View Object

In AD, microglial cells and astrocytes express NLRP3, which in turn can detect A beta plaques and act by secreting caspase-1 to activate IL-1 beta and IL- 18 [23–25]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

a(MESH:Astrocytes) increases p(HGNC:TLR4) View Subject | View Object

Pattern recognition receptors such as the TLR4 receptor are expressed in the brain’s own immune cells like microglia and astrocytes that induce inflammation via cytokine secretion [38]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Toll like receptor subgraph

a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) View Subject | View Object

NO can also bring about apoptosis of hippocampal neurons via caspase- 3 activity [50] whereas astrocyte-secreted IL-1 beta can increase the production of APP and A beta from neu- rons [51–53] (Fig. 1). PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph
NeuroMMSigDB
Nitric oxide subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.