1. Catalog
  2. Nodes
  3. complex(GO:"inflammasome complex")

complex(GO:"inflammasome complex")

Appears in Networks 3

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 29

bp(GO:autophagy) regulates complex(GO:"inflammasome complex") View Subject | View Object

Furthermore, autophagy can regulate both apoptosis and inflammasome assembly, and, depending on the conditions, can be either pro- or anti-apoptotic104 PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Apoptosis signaling subgraph

bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) View Subject | View Object

For inflammasome activation and IL-1β release, autophagy is a negative regulator: PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Interleukin signaling subgraph

complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

NLRP1 has been shown to bind directly to its ligand muramyl dipeptide in vitro and this was demonstrated to be sufficient to activate the assembly of an inflammasome. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High

complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) hasComponent complex(GO:"inflammasome complex") View Subject | View Object

Appears in Networks:

complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

However, a requirement for the interaction of NLRP1 with nucleotide-binding oligomerization domain-containing protein 2 (NOD2), which is another receptor for muramyl dipeptide, has been described. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium

a(CHEBI:"amyloid-beta") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") View Subject | View Object

In response to danger signals, inflammasomes assemble by self-oligomerizing the NLRs through interactions with the NACHT domain (van de Veerdonk et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Spinal cord injury elevates extracellular ATP levels during neuroinflammation, which may act on purinergic receptors to trigger the activation of inflammasome (de Rivero Vaccari et al., 2012; Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium

deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) View Subject | View Object

The activators of the inflammasomes can be divided into two categories; pathogen associated molecular patterns (PAMPs) activate a host-defense reaction, and damage associated molecular patterns (DAMPs) activate a self-defense mechanism in response to danger signals (Salminen et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:Alarmins) increases complex(GO:"inflammasome complex") View Subject | View Object

In response to danger signals, inflammasomes assemble by self-oligomerizing the NLRs through interactions with the NACHT domain (van de Veerdonk et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

The activators of the inflammasomes can be divided into two categories; pathogen associated molecular patterns (PAMPs) activate a host-defense reaction, and damage associated molecular patterns (DAMPs) activate a self-defense mechanism in response to danger signals (Salminen et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

Activators include bacteria, virus, fungus, protoza, microbial proteins, crystalline urea, RNA, Alum, ATP, potassium efflux, fatty acids, Aβ, and most recently, degraded mitochondrial DNA (Liu et al., 2013a; Mathew et al., 2012; Schmidt and Lenz, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") View Subject | View Object

In response to danger signals, inflammasomes assemble by self-oligomerizing the NLRs through interactions with the NACHT domain (van de Veerdonk et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) hasComponent complex(GO:"inflammasome complex") View Subject | View Object

Appears in Networks:

composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) hasComponent complex(GO:"inflammasome complex") View Subject | View Object

Appears in Networks:

p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") View Subject | View Object

Inflammasomes involve in the maturation of IL-1β and IL-18 are expressed in neurons (de Rivero Vaccari et al., 2008; Yang-Wei Fann et al., 2013; Zou and Crews, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") View Subject | View Object

Inflammasomes involve in the maturation of IL-1β and IL-18 are expressed in neurons (de Rivero Vaccari et al., 2008; Yang-Wei Fann et al., 2013; Zou and Crews, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) View Subject | View Object

P2X4 knock-out mice has been shown to decrease the level of IL-1β and to have impair inflammasome signaling (de Rivero Vaccari et al., 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") View Subject | View Object

Trauma, a risk factor for AD, increases inflammasome expression in rat neurons (de Rivero Vaccari et al., 2009; de Rivero Vaccari et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

path(MESH:Stroke) increases complex(GO:"inflammasome complex") View Subject | View Object

Furthermore, postmortem brain tissues from stroke patients show increase protein levels of inflammasomes in primary cortical neurons (Yang- Wei Fann et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") View Subject | View Object

They appear to be involved in several pathological processes activated by microbes including Alzheimer’s disease (AD). PubMed:27314526

Appears in Networks:
Annotations
Confidence
High

Out-Edges 34

complex(GO:"inflammasome complex") increases p(HGNC:IL18) View Subject | View Object

IL-1β and IL-18 are synthesized as inactive precursors, proIL-1β and proIL-18, respectively, and require inflammasomes for their maturation PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") hasComponent p(HGNC:AIM2) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:IFI16) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:DDX58) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) View Subject | View Object

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) View Subject | View Object

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:CASP1) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

Once the protein complexes have formed, the inflammasomes activate caspase 1, which proteolytically activates the pro-inflammatory cytokines interleukin-1β (IL-1β)3 and IL-18. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) View Subject | View Object

In addition, inflammasome activation causes a rapid, proinflammatory form of cell death called pyroptosis4. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Apoptosis signaling subgraph

complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP1) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP6) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP7) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRP12) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") hasComponent p(HGNC:NLRC4) View Subject | View Object

Appears in Networks:

complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Apoptosis signaling subgraph
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
XIAP subgraph

complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) View Subject | View Object

Inflammasomes involve in the maturation of IL-1β and IL-18 are expressed in neurons (de Rivero Vaccari et al., 2008; Yang-Wei Fann et al., 2013; Zou and Crews, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

IL-1β and IL-18 are synthesized as inactive precursors, proIL-1β and proIL-18, respectively, and require inflammasomes for their maturation PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) View Subject | View Object

However the maturation of IL-18 and IL-1β could be regulated by the same type of inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) View Subject | View Object

Inflammasomes involve in the maturation of IL-1β and IL-18 are expressed in neurons (de Rivero Vaccari et al., 2008; Yang-Wei Fann et al., 2013; Zou and Crews, 2012) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) View Subject | View Object

Like IL-1β, in most cases, the mature secretable form of IL-18 is generated by caspase-1 through the activation of inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") regulates p(HGNC:IL18) View Subject | View Object

However the maturation of IL-18 and IL-1β could be regulated by the same type of inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") hasComponent a(MESH:"NLR Proteins") View Subject | View Object

Appears in Networks:

act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) View Subject | View Object

Like IL-1β, in most cases, the mature secretable form of IL-18 is generated by caspase-1 through the activation of inflammasome PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) View Subject | View Object

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) View Subject | View Object

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) View Subject | View Object

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) View Subject | View Object

Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") View Subject | View Object

They appear to be involved in several pathological processes activated by microbes including Alzheimer’s disease (AD). PubMed:27314526

Appears in Networks:
Annotations
Confidence
High

act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) View Subject | View Object

Post activation of the inflammasome, caspase 1 enzyme initiates the maturation of pro-inflammatory cytokines particularly interleukin (IL)-1beta, IL-18, and IL-33 [4] (Fig. 1),and inflammation mediated cell death occurs via the nucleotide-binding domain and leucine-rich repeat(NLR) family of proteins [5]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

Both IL-1 beta and IL-18 are generated in their mature secreted form by caspase-1 through activa- tion of the inflammasome. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.