sec(p(HGNC:IL1B)) increases p(HGNC:APP)

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PubMed:27314526

NO can also bring about apoptosis of hippocampal neurons via caspase- 3 activity [50] whereas astrocyte-secreted IL-1 beta can increase the production of APP and A beta from neu- rons [51–53] (Fig. 1).

Related Edges 4

• a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3))
• a(MESH:Astrocytes) increases sec(p(HGNC:IL1B))
• act(p(HGNC:CASP3)) increases bp(GO:"neuron death")
• sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta")

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

NeuroMMSigDB

Amyloidogenic subgraph

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

Interleukin signaling subgraph

NeuroMMSigDB

Nitric oxide subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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