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  3. a(MESH:Interleukins)

a(MESH:Interleukins)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Interleukins
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 2

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

In-Edges 4

bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

path(MESH:Dementia) association sec(a(MESH:Interleukins)) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

a(CHEBI:resveratrol) decreases a(MESH:Interleukins) View Subject | View Object

Resveratrol crossed the blood-brain barrier (BBB) [111,112] and down-regulated several inflammatory biomarkers such as TNF-, COX2 and interleukins [113,114]. PubMed:29179999

Appears in Networks:

act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) View Subject | View Object

NF-B activation mediates the expression of the pro-oxidant NAPDH oxidase, cyclooxygenase 2 (COX2), interleukins and the antioxidant enzyme, superoxide dismutase (SOD) [78]. Additionally, NF-B activity is associated with the expression of BACE1 [79] and the activation of nucleotide-binding oligomerization domain-like receptor (NALP) 3 inflammosome [80]. PubMed:29179999

Appears in Networks:

Out-Edges 2

sec(a(MESH:Interleukins)) association path(MESH:Dementia) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) View Subject | View Object

This family serves several biological functions but if inappropriately secreted can lead to manifestation of depressive behaviors typ- ically associated with dementia onset and chronic neuroinflammation. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.