p(HGNC:IL18) increases a(CHEBI:"amyloid-beta")

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PubMed:27314526

Pro-inflammatory IL-18 increases AD-associated A beta deposition in human neuron-like cells in culture [55]. IL-18 also increases the expression of glycogen synthase kinase 3 beta (GSK-3 beta ) and cyclin-dependent kinase 5, both of which are involved in hyperphos- phorylation of the tau protein [56].

Related Edges 4

• p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:IL18) increases p(HGNC:GSK3B)
• p(HGNC:IL18) increases p(HGNC:CDK5)

Confidence

High

MeSH

Neurons

MeSH

Alzheimer Disease

NeuroMMSigDB

Amyloidogenic subgraph

NeuroMMSigDB

Cyclin-CDK subgraph

NeuroMMSigDB

GSK3 subgraph

NeuroMMSigDB

Interleukin signaling subgraph

NeuroMMSigDB

Tau protein subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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