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bp(MESH:Aging)

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Entity

Name
Aging
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 8

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats v1.0.0

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. v1.0.0

The Biology of Proteostasis in Aging and Disease v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity v1.0.0

In-Edges 10

p(MGI:Fkbp1b) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:Eif3g) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:Pla2g7) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:S100b) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:Snapc2) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

path(MESH:"Alzheimer Disease") association bp(MESH:Aging) View Subject | View Object

Age is the primary risk factor for AD, and the disease usually manifests in individuals after the age of 60 years. Due to an aging population, the prevalence of AD is predicted to rise to 66 million people by the year 2030. PubMed:24511233

Appears in Networks:

bp(HBP:Proteostasis) decreases bp(MESH:Aging) View Subject | View Object

As such, it is feasible that any reduction in the protein degradation capacity of a cell could contribute to proteostasis collapse and promote aging. PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) View Subject | View Object

Further, transgenic mouse lines expressing human tau aggregates in the entorhinal cortex have shown that tau is mislocalized from axons to cell bodies and dendrites as the mice age (Pooler et al., 2013b) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Entorhinal Cortex

tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) View Subject | View Object

Further, transgenic mouse lines expressing human tau aggregates in the entorhinal cortex have shown that tau is mislocalized from axons to cell bodies and dendrites as the mice age (Pooler et al., 2013b) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Entorhinal Cortex

path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) View Subject | View Object

Aging is the biggest risk factor for developing a neurodegenerative disease, but the specific factors which cause these predominantly sporadic diseases are still under investigation (Reeve et al., 2014). PubMed:29311797

Appears in Networks:

Out-Edges 65

bp(MESH:Aging) decreases p(MGI:Map2) View Subject | View Object

MAP2: downregulation with aging and restoration by FKBP1b PubMed:29255009

Appears in Networks:

bp(MESH:Aging) regulates p(MGI:Capn1) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

Appears in Networks:

bp(MESH:Aging) regulates p(MGI:Ppp3cc) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

Appears in Networks:

bp(MESH:Aging) association path(MESH:"Alzheimer Disease") View Subject | View Object

Age is the primary risk factor for AD, and the disease usually manifests in individuals after the age of 60 years. Due to an aging population, the prevalence of AD is predicted to rise to 66 million people by the year 2030. PubMed:24511233

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:TPR) View Subject | View Object

TPR proteins tend to be induced, whereas HSP40s are repressed (Figure 1B). PubMed:25437566

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:TPR) View Subject | View Object

Ranked by decreasing median aging correlation, the induction of sHSPs and TPR genes consistently ranked high and the HSP60s, HSP40s, and HSP70s were consistently repressed. PubMed:25437566

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:TPR) View Subject | View Object

Among the genes that are induced in brain aging and disease are sHSPs and TPR-containing chaperone genes (Figures S3A–S3D). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

TPR proteins tend to be induced, whereas HSP40s are repressed (Figure 1B). PubMed:25437566

Appears in Networks:

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

Among the genes that are repressed in both aging and AD, the HSP70- HSP40 system corresponds to 36% of the 58 genes (Table S3D). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

Ranked by decreasing median aging correlation, the induction of sHSPs and TPR genes consistently ranked high and the HSP60s, HSP40s, and HSP70s were consistently repressed. PubMed:25437566

Appears in Networks:

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

Among repressed genes, the HSP40s exhibited significant change (p = 0.04875), with 62% of 48 HSP40 genes repressed in aging (p < 0.05) and 51% repressed in AD. PubMed:25437566

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:Aging) decreases p(FPLX:HSPA) View Subject | View Object

Among the genes that are repressed in both aging and AD, the HSP70- HSP40 system corresponds to 36% of the 58 genes (Table S3D). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:Aging) decreases p(FPLX:HSPA) View Subject | View Object

Ranked by decreasing median aging correlation, the induction of sHSPs and TPR genes consistently ranked high and the HSP60s, HSP40s, and HSP70s were consistently repressed. PubMed:25437566

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSPB) View Subject | View Object

Ranked by decreasing median aging correlation, the induction of sHSPs and TPR genes consistently ranked high and the HSP60s, HSP40s, and HSP70s were consistently repressed. PubMed:25437566

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSPB) View Subject | View Object

Among the genes that are induced in brain aging and disease are sHSPs and TPR-containing chaperone genes (Figures S3A–S3D). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:Aging) decreases p(HGNC:HSPD1) View Subject | View Object

Ranked by decreasing median aging correlation, the induction of sHSPs and TPR genes consistently ranked high and the HSP60s, HSP40s, and HSP70s were consistently repressed. PubMed:25437566

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:HSPA2) View Subject | View Object

For example, concordantly aggravated expression pat- terns for the aging-induced genes HSPA2 (HSP70) and DNAJB2 (HSP40) and the aging-repressed HSPA12A (HSP70) and TOMM70A (TPR) were observed in brain biopsies from AD, HD, and PD patients (Figure 2C). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) increases p(HGNC:DNAJB2) View Subject | View Object

For example, concordantly aggravated expression pat- terns for the aging-induced genes HSPA2 (HSP70) and DNAJB2 (HSP40) and the aging-repressed HSPA12A (HSP70) and TOMM70A (TPR) were observed in brain biopsies from AD, HD, and PD patients (Figure 2C). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:HSPA12A) View Subject | View Object

For example, concordantly aggravated expression pat- terns for the aging-induced genes HSPA2 (HSP70) and DNAJB2 (HSP40) and the aging-repressed HSPA12A (HSP70) and TOMM70A (TPR) were observed in brain biopsies from AD, HD, and PD patients (Figure 2C). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:TOMM70) View Subject | View Object

For example, concordantly aggravated expression pat- terns for the aging-induced genes HSPA2 (HSP70) and DNAJB2 (HSP40) and the aging-repressed HSPA12A (HSP70) and TOMM70A (TPR) were observed in brain biopsies from AD, HD, and PD patients (Figure 2C). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:HSP90AB1) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:HSPA8) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:HSPA14) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) decreases p(HGNC:TCP1) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

bp(MESH:Aging) regulates bp(HBP:Proteostasis) View Subject | View Object

Furthermore, the activity of the PN can be altered permanently or transiently by development and aging, alterations in physiology, or exposure to environmental stress (1). PubMed:25784053

Appears in Networks:

bp(MESH:Aging) decreases p(FPLX:HSPA) View Subject | View Object

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

bp(MESH:Aging) decreases p(FPLX:HSP90) View Subject | View Object

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

bp(MESH:Aging) increases p(FPLX:HSPB) View Subject | View Object

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") View Subject | View Object

Aging, a major risk factor for AD, affects both the UPS and autophagy. PubMed:23528736

Appears in Networks:

bp(MESH:Aging) decreases bp(GO:autophagy) View Subject | View Object

Aging, a major risk factor for AD, affects both the UPS and autophagy. PubMed:23528736

Appears in Networks:

bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) View Subject | View Object

Aging, a major risk factor for AD, affects both the UPS and autophagy. PubMed:23528736

Appears in Networks:

bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) View Subject | View Object

Further, transgenic mouse lines expressing human tau aggregates in the entorhinal cortex have shown that tau is mislocalized from axons to cell bodies and dendrites as the mice age (Pooler et al., 2013b) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Entorhinal Cortex

bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) View Subject | View Object

Further, transgenic mouse lines expressing human tau aggregates in the entorhinal cortex have shown that tau is mislocalized from axons to cell bodies and dendrites as the mice age (Pooler et al., 2013b) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Entorhinal Cortex

bp(MESH:Aging) decreases p(HGNC:PPP5C) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(HGNC:AHSA1) View Subject | View Object

Since Aha1 levels are repressed in aging, but are abnormally preserved in AD, tau aggregation could be accelerated in part by Aha1 in the AD brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") View Subject | View Object

Aging is the biggest risk factor for developing a neurodegenerative disease, but the specific factors which cause these predominantly sporadic diseases are still under investigation (Reeve et al., 2014). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases bp(GO:"protein folding") View Subject | View Object

Not only does aging lead to an increased likelihood of protein misfolding and aggregation, it is compounded by a decrease in the efficiency of the protein degradation machinery. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") View Subject | View Object

Not only does aging lead to an increased likelihood of protein misfolding and aggregation, it is compounded by a decrease in the efficiency of the protein degradation machinery. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases bp(MESH:Proteolysis) View Subject | View Object

Not only does aging lead to an increased likelihood of protein misfolding and aggregation, it is compounded by a decrease in the efficiency of the protein degradation machinery. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:AHSA1) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) View Subject | View Object

The activity of both the proteasome, which is the main mechanism of protein degradation (Rock et al., 1994; Conconi et al., 1996), and chaperone-mediated autophagy (CMA; Cuervo and Dice, 2000b) is significantly impaired with aging and is especially pronounced in post-mitotic cells, such as neurons, potentially resulting in neurodegenerative disease (Terman, 2001). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) View Subject | View Object

In addition to the problems faced with an overwhelmed chaperone network, the proteolytic activity of the proteasome also declines with aging, and in fact Hsp90 has been shown to protect the proteasome from age-related, oxidative-dependent decline (Conconi and Friguet, 1997). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") View Subject | View Object

The activity of both the proteasome, which is the main mechanism of protein degradation (Rock et al., 1994; Conconi et al., 1996), and chaperone-mediated autophagy (CMA; Cuervo and Dice, 2000b) is significantly impaired with aging and is especially pronounced in post-mitotic cells, such as neurons, potentially resulting in neurodegenerative disease (Terman, 2001). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") View Subject | View Object

Proteins can also be degraded by CMA; however, CMA activity also decreases with age (Cuervo and Dice, 2000a). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:PPID) View Subject | View Object

An interesting PPIase, CyP40, decreases in aging and is further repressed in AD (Table 1; Brehme et al., 2014). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:PPID) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) increases p(HGNC:FKBP5) View Subject | View Object

However, throughout aging, FKBP51 levels progressively increase and are further increased in AD brain samples (Table 1; Blair et al., 2013; Sabbagh et al., 2014). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:FKBP5) View Subject | View Object

Interestingly, one co-chaperone is significantly induced in the aged brain and that is FKBP51. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(HGNC:PPP5C) View Subject | View Object

Another member of this family, protein phosphatase 5 (PP5), is repressed in aging. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

bp(MESH:Aging) increases p(FPLX:HSP90) View Subject | View Object

One study focused on the basal levels of cytosolic Hsp90 in peripheral blood mononuclear cells (PBMC) and found that in aged human samples there was an increase in Hsp90 under normal physiological conditions when compared to young samples (Njemini et al., 2007). PubMed:29311797

Appears in Networks:
Annotations
Cell Ontology (CL)
peripheral blood mononuclear cell

bp(MESH:Aging) decreases p(FPLX:HSP90) View Subject | View Object

Conversely, there are also studies showing decreased levels of Hsp90 in aged human brain samples. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(FPLX:HSP90) View Subject | View Object

One study found that cytosolic Hsp90 was repressed in the superior frontal gyrus, while another demonstrated a similar repression in the prefrontal cortex of aged patients compared to controls (Berchtold et al., 2008; Loerch et al., 2008; Brehme et al., 2014). PubMed:29311797

Appears in Networks:
Annotations
Uberon
prefrontal cortex
Uberon
superior frontal gyrus

bp(MESH:Aging) decreases p(HGNC:FKBP4) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(HGNC:STIP1) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(HGNC:PTGES3) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ac)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(NO)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") View Subject | View Object

The HSP40, HSP60 and HSP70 families were amongst the most repressed chaperones, with HSP70s being the most repressed group overall. However, in contrast with the broad spectrum of repressed chaperone families, sHSPs and the TPR co-chaperone proteins were the only families that were significantly induced. PubMed:27491084

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:HSPD1) View Subject | View Object

The HSP40, HSP60 and HSP70 families were amongst the most repressed chaperones, with HSP70s being the most repressed group overall. However, in contrast with the broad spectrum of repressed chaperone families, sHSPs and the TPR co-chaperone proteins were the only families that were significantly induced. PubMed:27491084

Appears in Networks:

bp(MESH:Aging) decreases p(FPLX:HSPA) View Subject | View Object

The HSP40, HSP60 and HSP70 families were amongst the most repressed chaperones, with HSP70s being the most repressed group overall. However, in contrast with the broad spectrum of repressed chaperone families, sHSPs and the TPR co-chaperone proteins were the only families that were significantly induced. PubMed:27491084

Appears in Networks:

bp(MESH:Aging) increases p(HGNC:TPR) View Subject | View Object

The HSP40, HSP60 and HSP70 families were amongst the most repressed chaperones, with HSP70s being the most repressed group overall. However, in contrast with the broad spectrum of repressed chaperone families, sHSPs and the TPR co-chaperone proteins were the only families that were significantly induced. PubMed:27491084

Appears in Networks:

bp(MESH:Aging) increases p(FPLX:HSPB) View Subject | View Object

The HSP40, HSP60 and HSP70 families were amongst the most repressed chaperones, with HSP70s being the most repressed group overall. However, in contrast with the broad spectrum of repressed chaperone families, sHSPs and the TPR co-chaperone proteins were the only families that were significantly induced. PubMed:27491084

Appears in Networks:

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