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FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:09:39.178226
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
28
Number Edges
46
Number Components
1
Network Density
0.0608465608465608
Average Degree
1.64285714285714
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease v1.0.0 11%
Tau Modifications v1.9.5 11%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 8%
albuquerque2009 v1.0.0 7%
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1 7%
The Biology of Proteostasis in Aging and Disease v1.0.0 7%
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0 7%
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0 7%
Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0 7%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 7%

Sample Edges

a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Genes in the mTOR pathway were also of specific interest because this pathway is inhibited by the immunosuppressant drug rapamy- cin via complex formation with FKBP1b/1a. PubMed:29255009

bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) View Subject | View Object

Nevertheless, the lack of change in mTOR pathway gene expression suggests that FKBP1b’s genomic effects were not mediated by the mTOR pathway. PubMed:29255009

bp(MESH:Aging) decreases p(MGI:Map2) View Subject | View Object

MAP2: downregulation with aging and restoration by FKBP1b PubMed:29255009

bp(MESH:Aging) regulates p(MGI:Capn1) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

bp(MESH:Aging) regulates p(MGI:Ppp3cc) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

Sample Nodes

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

a(CHEBI:sirolimus)

In-Edges: 8 | Out-Edges: 50 | Explore Neighborhood | Download JSON

a(GO:"cytoplasmic vesicle")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

bp(GO:"blood vessel development")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

bp(GO:"ectoderm development")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.