bp(MESH:Aging) decreases act(p(FPLX:Proteasome))

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PubMed:29311797

The activity of both the proteasome, which is the main mechanism of protein degradation (Rock et al., 1994; Conconi et al., 1996), and chaperone-mediated autophagy (CMA; Cuervo and Dice, 2000b) is significantly impaired with aging and is especially pronounced in post-mitotic cells, such as neurons, potentially resulting in neurodegenerative disease (Terman, 2001).

Related Edges 1

• bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy")

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