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Appears in Networks 1

In-Edges 2

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Out-Edges 1

p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) View Subject | View Object

S-nitrosylation, oxidation and ubiquitination also inhibit Hsp90 chaperone activity (Blank et al., 2003; Martínez-Ruiz et al., 2005; Chen et al., 2008). PubMed:29311797


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.