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p(HGNC:PPID)

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
PPID
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

In-Edges 4

complex(p(FPLX:HSP90), p(HGNC:PPID)) hasComponent p(HGNC:PPID) View Subject | View Object

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:PPID) View Subject | View Object

An interesting PPIase, CyP40, decreases in aging and is further repressed in AD (Table 1; Brehme et al., 2014). PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:PPID) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) View Subject | View Object

An interesting PPIase, CyP40, decreases in aging and is further repressed in AD (Table 1; Brehme et al., 2014). PubMed:29311797

Appears in Networks:

Out-Edges 5

p(HGNC:PPID) isA a(MESH:Immunophilins) View Subject | View Object

Appears in Networks:

p(HGNC:PPID) decreases a(HBP:"Tau fibrils") View Subject | View Object

CyP40 was recently shown to disaggregate tau fibrils in vitro and prevents toxic tau accumulation in vivo preserving memory, demonstrating a neuroprotective role for CyP40 in the brain (Baker et al., 2017). PubMed:29311797

Appears in Networks:

p(HGNC:PPID) decreases a(HBP:"Tau aggregates") View Subject | View Object

CyP40 was recently shown to disaggregate tau fibrils in vitro and prevents toxic tau accumulation in vivo preserving memory, demonstrating a neuroprotective role for CyP40 in the brain (Baker et al., 2017). PubMed:29311797

Appears in Networks:

p(HGNC:PPID) increases bp(GO:memory) View Subject | View Object

CyP40 was recently shown to disaggregate tau fibrils in vitro and prevents toxic tau accumulation in vivo preserving memory, demonstrating a neuroprotective role for CyP40 in the brain (Baker et al., 2017). PubMed:29311797

Appears in Networks:

p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") View Subject | View Object

CyP40 was recently shown to disaggregate tau fibrils in vitro and prevents toxic tau accumulation in vivo preserving memory, demonstrating a neuroprotective role for CyP40 in the brain (Baker et al., 2017). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.