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p(MGI:Fkbp1b)

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Entity

Name
Fkbp1b
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats v1.0.0

In-Edges 3

bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) View Subject | View Object

Nevertheless, the lack of change in mTOR pathway gene expression suggests that FKBP1b’s genomic effects were not mediated by the mTOR pathway. PubMed:29255009

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complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b)) hasComponent p(MGI:Fkbp1b) View Subject | View Object

Appears in Networks:

p(HBP:"AAV-FKBP1B") increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) View Subject | View Object

AAV-FKBP1b injection increased hippocampal FKBP1b protein and gene expression, particularly in the LT group PubMed:29255009

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Out-Edges 19

p(MGI:Fkbp1b) increases path(MESH:Memory) View Subject | View Object

FKBP1b overexpression improved spatial reference and reversal memory for both LT and ST aged groups PubMed:29255009

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p(MGI:Fkbp1b) increases bp(MESH:Aging) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

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p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

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p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:Fkbp1b) increases act(p(MGI:S100b)) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

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p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) View Subject | View Object

Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100􏰌, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009

Appears in Networks:

p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") View Subject | View Object

Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") View Subject | View Object

Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") View Subject | View Object

Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) View Subject | View Object

Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) View Subject | View Object

Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") View Subject | View Object

Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") View Subject | View Object

Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") View Subject | View Object

Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009

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p(MGI:Fkbp1b) decreases tloc(a(CHEBI:"calcium(2+)")) View Subject | View Object

Because FKBP1b is a negative regulator of hippocampal neuronal Ca2􏰅 transients PubMed:29255009

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p(MGI:Fkbp1b) regulates p(MGI:Capn1) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

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p(MGI:Fkbp1b) regulates p(MGI:Ppp3cc) View Subject | View Object

Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2􏰅 release-activated Ca2􏰅 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009

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p(MGI:Fkbp1b) decreases p(MGI:Hif1an) View Subject | View Object

Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 􏰆 0.78, binomial test). PubMed:29255009

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p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) View Subject | View Object

Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 􏰆 0.78, binomial test). PubMed:29255009

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.