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p(HGNC:HSP90AB1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HSP90AB1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. v1.0.0

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

In-Edges 16

complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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bp(MESH:Aging) decreases p(HGNC:HSP90AB1) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) View Subject | View Object

Four genes that are significantly repressed both in AD and HD (HSP90AB1, HSPA8, HSPA14, and TCP1) are also repressed in aging (Figure 6B). PubMed:25437566

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease
MeSH
Huntington Disease
MeSH
Parkinson Disease

complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:AR), p(HGNC:HSP90AB1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

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bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

bp(GO:"cell maturation") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Germ Cells

bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

bp(GO:"embryo development") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

bp(GO:"signal transduction") association p(HGNC:HSP90AB1) View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

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Out-Edges 6

p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) View Subject | View Object

Hsp90beta interacted particularly strongly with kinases (Figure 5B, filled blue circles), whereas the transcription factors p53 and HSF1 were among the most Hsp70-biased interactors (Figure 5B,green circles) PubMed:25036637

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p(HGNC:HSP90AB1) association bp(GO:"embryo development") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

p(HGNC:HSP90AB1) association bp(GO:"cell maturation") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Germ Cells

p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

p(HGNC:HSP90AB1) association bp(GO:"signal transduction") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") View Subject | View Object

Hsp90α is involved in growth promotion, cell cycle regulation, stress-induced cytoprotection, and cancer cell invasiveness; whereas Hsp90β is involved with early embryonic development, germ cell maturation, cytoskeletal stabilization, cellular transformation, signal transduction, and long-term cell adaptation (Eustace et al., 2004; Sreedhar et al., 2004). PubMed:29311797

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.