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p(HGNC:PPP5C)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPP5C
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 5

complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) hasComponent p(HGNC:PPP5C) View Subject | View Object

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:PPP5C) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

bp(MESH:Aging) decreases p(HGNC:PPP5C) View Subject | View Object

Another member of this family, protein phosphatase 5 (PP5), is repressed in aging. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

complex(p(FPLX:HSP90), p(HGNC:PPP5C)) hasComponent p(HGNC:PPP5C) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) View Subject | View Object

PP5 activity has been shown to be repressed in AD (Table 1; Liu et al., 2005). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

Out-Edges 3

p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

In general, phosphorylation of tau reduces its affinity for microtubules [30], while dephosphorylation via enzymes such as PP2A and PP5 restores binding PubMed:21882945

Appears in Networks:

act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Studies have shown that PP5 is able to dephosphorylate tau at several phosphorylation sites connected to AD pathology (Gong et al., 2004). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Protein phosphatase 1 (PP1), PP2A, PP2B, PP2C and PP5 have all been implicated in the dephosphorylation of tau PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.