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Appears in Networks 4

In-Edges 5

Out-Edges 3

p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

In general, phosphorylation of tau reduces its affinity for microtubules [30], while dephosphorylation via enzymes such as PP2A and PP5 restores binding PubMed:21882945

act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Studies have shown that PP5 is able to dephosphorylate tau at several phosphorylation sites connected to AD pathology (Gong et al., 2004). PubMed:29311797

p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Protein phosphatase 1 (PP1), PP2A, PP2B, PP2C and PP5 have all been implicated in the dephosphorylation of tau PubMed:26631930


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.