1. Catalog
  2. Nodes
  3. p(HGNC:FKBP4)

p(HGNC:FKBP4)

Equivalencies: 0 | Classes: 1 | Children: 1 | Explore

Entity

Name
FKBP4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Tau in physiology and pathology v1.0.0

In-Edges 10

complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

complex(p(FPLX:HSP90), p(HGNC:FKBP4)) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:FKBP4) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

complex(p(FPLX:HSP90), p(HGNC:FKBP4), p(HGNC:PTGES3), p(HGNC:STIP1)) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:FKBP4), p(HGNC:MAPT)) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) View Subject | View Object

However, it is interesting to note that FKBP52 levels are lower in the cortex of AD patients’ brains (Table 1; Brehme et al., 2014; Meduri et al., 2016). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

complex(p(HGNC:FKBP4), p(SFAM:"HSP90 Family")) hasComponent p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) View Subject | View Object

Appears in Networks:

p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) View Subject | View Object

We identified a novel molecular interaction implying the PHF6 peptide of Tau and the FK1/FK2 domains of FKBP52 independent of FK506 binding; suggesting a non-catalytic molecular interaction that might govern the effect of FKBP52 on Tau. PubMed:26903089

Appears in Networks:

Out-Edges 5

p(HGNC:FKBP4) isA a(MESH:Immunophilins) View Subject | View Object

Appears in Networks:

p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") View Subject | View Object

FKBP52 interacts both physically and functionally with tau and promotes tau aggregation in vitro (Giustiniani et al., 2015; Meduri et al., 2016). PubMed:29311797

Appears in Networks:

p(HGNC:FKBP4) hasVariant p(HGNC:FKBP4, frag("270_386")) View Subject | View Object

Appears in Networks:

act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") View Subject | View Object

We identified a novel molecular interaction implying the PHF6 peptide of Tau and the FK1/FK2 domains of FKBP52 independent of FK506 binding; suggesting a non-catalytic molecular interaction that might govern the effect of FKBP52 on Tau. PubMed:26903089

Appears in Networks:

p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") View Subject | View Object

Notably, two proteins — 14‑3‑3ζ and immunophilin (also known as FKBP52 or FKBP4) — have also been shown to induce aggregation of recombinant tau in vitro, presumably by stabilizing an aggregation-prone conformation of tau. PubMed:26631930

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.