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bp(MESH:Proteolysis)

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Entity

Name
Proteolysis
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 4

The Biology of Proteostasis in Aging and Disease v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

In-Edges 10

a(MESH:Lysosomes) increases bp(MESH:Proteolysis) View Subject | View Object

. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053

Appears in Networks:

bp(HBP:Proteostasis) association bp(MESH:Proteolysis) View Subject | View Object

Proteome fidelity is maintained by the protein homeostasis (proteostasis) network (PN), a multi-compartmental system that coordinatesprotein synthesis, folding, disaggregation, and degradation (1). PubMed:25784053

Appears in Networks:

p(FPLX:HSPA) regulates bp(MESH:Proteolysis) View Subject | View Object

As such, HSP70 and HSP90 are central to the process of triaging proteins for refolding or elimination. PubMed:25784053

Appears in Networks:

p(FPLX:HSP90) regulates bp(MESH:Proteolysis) View Subject | View Object

As such, HSP70 and HSP90 are central to the process of triaging proteins for refolding or elimination. PubMed:25784053

Appears in Networks:

p(FPLX:Proteasome) increases bp(MESH:Proteolysis) View Subject | View Object

. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) View Subject | View Object

All three proteolytic activities have been reported to be decreased in AD brains (Keller et al., 2000). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain

p(MGI:Tfeb) increases bp(MESH:Proteolysis) View Subject | View Object

Flow cytometry analysis of primary astrocytes incubated with DQ-BSA revealed an ∼60% increase in median fluorescence for TFEB-transduced astro- cytes, indicating that TFEB enhances uptake and proteolysis of DQ-BSA PubMed:30108137

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte

a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) View Subject | View Object

All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797

Appears in Networks:

bp(MESH:Aging) decreases bp(MESH:Proteolysis) View Subject | View Object

Not only does aging lead to an increased likelihood of protein misfolding and aggregation, it is compounded by a decrease in the efficiency of the protein degradation machinery. PubMed:29311797

Appears in Networks:

act(p(FPLX:HSP90)) increases bp(MESH:Proteolysis) View Subject | View Object

Hsp90 requires ATP to perform these functions including protein degradation, protein folding, prevention of protein aggregation, and protein modification (Echeverría et al., 2011). PubMed:29311797

Appears in Networks:

Out-Edges 2

bp(MESH:Proteolysis) association bp(HBP:Proteostasis) View Subject | View Object

Proteome fidelity is maintained by the protein homeostasis (proteostasis) network (PN), a multi-compartmental system that coordinatesprotein synthesis, folding, disaggregation, and degradation (1). PubMed:25784053

Appears in Networks:

bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") View Subject | View Object

All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.