1. Catalog
  2. Nodes
  3. p(HGNC:AHSA1)

p(HGNC:AHSA1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
AHSA1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0

In-Edges 6

complex(p(HGNC:AHSA1), p(HGNC:CDC37)) hasComponent p(HGNC:AHSA1) View Subject | View Object

Appears in Networks:

bp(MESH:Aging) decreases p(HGNC:AHSA1) View Subject | View Object

Since Aha1 levels are repressed in aging, but are abnormally preserved in AD, tau aggregation could be accelerated in part by Aha1 in the AD brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

bp(MESH:Aging) decreases p(HGNC:AHSA1) View Subject | View Object

For instance, CyP40, FKBP52, PP5, Hop, p23, and Aha1 are all repressed in the aged brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) View Subject | View Object

Aha1 levels have been shown to increase with AD. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) View Subject | View Object

Previous studies have also implicated Aha1 for a role in cystic fibrosis. PubMed:29311797

Appears in Networks:

complex(p(HGNC:AHSA1), p(HGNC:MAPT)) hasComponent p(HGNC:AHSA1) View Subject | View Object

Appears in Networks:

Out-Edges 10

p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) View Subject | View Object

As in the case of Hsp70, cochaperones of Hsp90, such as Aha1, cdc37 and TPR domain-containing proteins, regulate its ATPase activity and control its conformational transitions (reviewed in [84]). PubMed:21882945

Appears in Networks:

p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) View Subject | View Object

In addition, Hsp90’s hydrolysis of ATP, which is stimulated by Aha1, facilitates polypeptide release [82,106] and transfer to CHIP or other E3 ligases [107,108] PubMed:21882945

Appears in Networks:

p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) View Subject | View Object

In addition, Hsp90’s hydrolysis of ATP, which is stimulated by Aha1, facilitates polypeptide release [82,106] and transfer to CHIP or other E3 ligases [107,108] PubMed:21882945

Appears in Networks:

p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) View Subject | View Object

The activator of Hsp90 ATPase homolog 1 (Aha1) works as a co- chaperone to stimulate the ATPase function of Hsp90 to regulate the folding and activation of client proteins. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Aha1 levels have been shown to increase with AD. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:AHSA1) increases a(HBP:"Tau oligomers") View Subject | View Object

In the same study, we found that high levels of Aha1 in a tau transgenic mouse model increased tau oligomers as well as neuronal loss concomitant with cognitive deficits (Shelton et al., 2017). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:AHSA1) increases bp(GO:"neuron apoptotic process") View Subject | View Object

In the same study, we found that high levels of Aha1 in a tau transgenic mouse model increased tau oligomers as well as neuronal loss concomitant with cognitive deficits (Shelton et al., 2017). PubMed:29311797

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") View Subject | View Object

Since Aha1 levels are repressed in aging, but are abnormally preserved in AD, tau aggregation could be accelerated in part by Aha1 in the AD brain. PubMed:29311797

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") View Subject | View Object

Previous studies have also implicated Aha1 for a role in cystic fibrosis. PubMed:29311797

Appears in Networks:

p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) View Subject | View Object

The activator of Hsp90 ATPase (Aha1) binds asymmetrically to the Hsp90 middle domain, stimulating ATP hydrolysis and inducing transition to the closed state (180, 181, 185, 190). PubMed:23746257

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.