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Appears in Networks 1

In-Edges 2

bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) View Subject | View Object

These PTMs increase with aging and can alter the ability of Hsp90 to function properly as well as change the ability of different co-chaperones to bind. PubMed:29311797

Out-Edges 1

p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) View Subject | View Object

Phosphorylation of Hsp90 leads to reduced chaperoning ability and phosphorylation of specific tyrosine residues can affect the ability of Hsp90 to interact with distinct client proteins (Zhao et al., 2001; Mollapour and Neckers, 2012). PubMed:29311797


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.