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PubMed: 25652642

Title
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis.
Journal
Expert opinion on therapeutic targets
Volume
19
Issue
None
Pages
471-87
Date
2015-04-01
Authors
Srinivasan M | Lahiri DK

Evidence 34fa367392
JSON

Unlike neurons, NF-κB is present in the cytoplasm as an inactive complex with the IκB proteins in glial cells under physiological conditions

a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Cytoplasm
MeSH
Neuroglia

Evidence 2771d38145
JSON

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner

a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 630a5711d2
JSON

Excessive accumulation of Aβ1-42 stimulates microglial cells by signaling via receptor associated advanced glycation end products (RAGE) and peroxisome proliferator-activated receptor-γ (PPAR-γ), phosphorylates IKK proteins, and enhances NF-κB mediated transactivation of inflammatory cytokines and neurotoxic molecules such as glutamate and reactive oxygen species (ROS)/induced nitric oxide synthase (iNOS) [12] (Fig 2B)

a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence d9b516b80c
JSON

Exposure of primary neuronal cells or post-mitotic neurons to Aβ1-42 peptide has been shown to strongly activate the p50:p65 dimers and mediate neuronal cell death (Fig 1)

a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence fcb655cc35
JSON

Under physiological conditions activation of NF-κB by endogenous Aβ reduces βAPP, BACE1 and the γ-secretase activity, thereby lowering Aβ processing and facilitating Aβ homeostasis

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") View Subject | View Object

Appears in Networks:

act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing") View Subject | View Object

Appears in Networks:

act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

Evidence 6445af5a06
JSON

However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production

a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence a7e5961926
JSON

Mechanistically, the Aβ induced neuronal apoptosis has been attributed to the increase in the ratio of proapoptotic gene (BAX) transcription to that of the anti-apoptotic gene Bcl-Xl, and/or to the reduction in constitutively activated NF-κB with consequent increase in the cytoplasmic IκB proteins

a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 4f6c8c090a
JSON

This is supported by the observation that in mixed neuronal-glial cell cultures, Aβ induces increasing degree of neurotoxicity in an NF-κB dependent manner in the presence of higher proportion of glial cells

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence a5c98f4ab8
JSON

Aβ has been shown to upregulate APOE in astroglial cells. This upregulation was inhibited by decoy-κB nucleotides supporting a critical role for NFκB in APOE function

a(CHEBI:"amyloid-beta") increases act(p(HGNC:APOE)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Astrocytes
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Astrocytes
MeSH
Alzheimer Disease

act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Astrocytes
MeSH
Alzheimer Disease

Evidence 13981fcebb
JSON

Glutamate induced stimulation of cerebellar granule cells via the N-methyl-D-aspartate (NMDA) receptor activate p65:p50 dimers and enhance transactivation of pro-apoptotic factors

a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) View Subject | View Object

Appears in Networks:

a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) View Subject | View Object

Appears in Networks:

act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Evidence 046081677d
JSON

A consequence of intracellular and parenchymal accumulation of NPs and NFTs is activation of NF-κB in the neural and glial cells with subsequent protective or detrimental effects

a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 3b12264343
JSON

Increased presence of activated glial cells presenting elevated NF-κB and HLA-DR expression are commonly observed around the Aβ plaques in postmortem AD tissue

a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 03fd4821c2
JSON

In primary neuronal cells, exposure to Aβ25-35 peptide increase NF-κB mediated transactivation of manganese superoxide dismutase (Mn-SOD), suppress peroxinitrite production and inhibit membrane depolarization, thereby preventing apoptosis induced by oxidative stress

a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 4445b6ee98
JSON

Several kinase pathways including the calcium-calmodium dependent kinase-II (CaMK), the protein kinases-C (PKC) and the ras/phosphatidylinositol 3-kinase (PI3K) pathways have been implicated in activating neuronal NF-κB signaling

bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons

bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons

Evidence 049e3c9fda
JSON

A number of physiological stimuli including membrane depolarization or glutamergic signal transduction lead to rapid activation of the inducible NF-κB localized in the synapses, cytoplasm and dendrites of the neurons

bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Cytoplasm
MeSH
Dendrites
MeSH
Neurons
MeSH
Synapses

bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Cytoplasm
MeSH
Dendrites
MeSH
Neurons
MeSH
Synapses

Evidence 5351c03c8b
JSON

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

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act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") View Subject | View Object

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act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Appears in Networks:

Evidence 7b44d4bdb3
JSON

Complete abrogation of the DNA binding ability of NFκB factors induces apoptosis of the neuronal cells

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons

Evidence a7d43c1668
JSON

Cell death is preceded by reduction in the NF-κB regulated transcription of anti-apoptotic genes suggesting that a minimal threshold of NF-κB activity is needed for neuronal survival

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Evidence d581057353
JSON

Various endogenous and exogenous stimuli activate NF-κB enhancing transactivation of inflammatory molecules and production of free radicals in glial cells

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia

act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neuroglia

Evidence de5213d978
JSON

Decoy κB nucleotides mediate cell death by blocking neurotrophins and anti-apoptotic factors supporting an essential role for NF-κB in the neuroprotective process

complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 2f6b27e473
JSON

These NF-κB mediated neuroprotective effects have been largely observed in early stages of neuronal regeneration in AD

complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence d612548179
JSON

Comparison of the cellular distribution of NF-κB in the nucleus basalis of Meynert of AD and control patients showed that the proportion of large cholinergic neurons with elevated nuclear p65 was significantly increased in AD, suggesting an association between NF–κB functions and the process of cholinergic degeneration

act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 25c1b4b3a6
JSON

These observations substantiate a direct role of neuronal NF–κB activation in the pathogenesis of AD

act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence ce7cef59b7
JSON

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients

complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 5838b6e674
JSON

Furthermore NF-κB specific inhibitor prevents iNOS and ROS upregulation in Aβ stimulated cultures of astrocytes or mixed cortical cells

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 20613975bd
JSON

Upregulation of several NF-κB regulated miRNAs such as miRNA-9, miRNA-34a, miRNA-125b, miRNA-146a, miRNA-155 and miRNA-339 5p have been observed in stressed primary human neuronalglial cells and in postmortem AD brain tissues

complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:"MIR9-1") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:"MIR9-1") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neuroglia
MeSH
Alzheimer Disease

Evidence da35a18836
JSON

The constitutive form is transcriptionally active as evidenced by the nuclear localization of the p50 and p65 subunits in the neurons of the cortex and hippocampus

complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

Evidence 2d9c25bd5b
JSON

In metabotrophic glutamate receptor-5 (mGlu5) agonist pretreated primary cortical neurons or neuroblastoma cells, Aβ induced toxicity was suppressed by selective activation of c-rel containing NF-κB dimers and transactivation of anti-apoptotic genes, Mn-SOD and Bcl-Xl [26] (Figs 1B, 2A)

complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:GRM5) increases act(p(HGNC:SOD2)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 4d870f6f9f
JSON

. Consistent with the cellular studies, increased immunostaining for NF-κB-p65 has been observed in neurons and their processes in the hippocampal formation and entorhinal cortex in AD

complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 6422d9a0e5
JSON

Stimulation with the Aβ25-35 fragments induces secretion of cytokines such as TNF-α and of neurotrophic factors such as nerve growth factor (NGF) and brain derived nerve factor (BDNF) in NF-κB-dependent manner

composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:TNF)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:NGF)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Evidence 66a24dbd50
JSON

In AD brains, miRNA-125b is observed as the most abundant exhibiting strong positive correlation with glial fibrillary acidic protein and vimentin and negative correlation with reduced cyclin dependent kinase 2A

m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

Evidence 8f4ddf24de
JSON

Stimulation of neuronal cells by TNF-α has been shown to upregulate transactivation of anti-apoptotic gene products and neurotrophins such as Bcl-2 and NGF respectively

p(HGNC:TNF) increases p(HGNC:NGF) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:TNF) increases p(HGNC:BCL2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.