a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1)

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PubMed:25652642

Mechanistically, the Aβ induced neuronal apoptosis has been attributed to the increase in the ratio of proapoptotic gene (BAX) transcription to that of the anti-apoptotic gene Bcl-Xl, and/or to the reduction in constitutively activated NF-κB with consequent increase in the cytoplasmic IκB proteins

Related Edges 4

• a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex"))
• a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death")
• a(CHEBI:"amyloid-beta") increases p(HGNC:BAX)
• a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins")

MeSH

Alzheimer Disease

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