complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta"))

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PubMed:25652642

In metabotrophic glutamate receptor-5 (mGlu5) agonist pretreated primary cortical neurons or neuroblastoma cells, Aβ induced toxicity was suppressed by selective activation of c-rel containing NF-κB dimers and transactivation of anti-apoptotic genes, Mn-SOD and Bcl-Xl [26] (Figs 1B, 2A)

Related Edges 5

• act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta"))
• p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL))
• p(HGNC:GRM5) increases act(p(HGNC:SOD2))
• p(HGNC:GRM5) increases act(p(HGNC:BCL2L1))
• act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta"))

MeSH

Neurons

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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