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a(HM:"stored erythrocytes")

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Entity

Name
stored erythrocytes
Namespace
HM
Namespace Version
None
Pattern
.*

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 26

a(CHEBI:"iron(2+)") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

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a(CHEBI:heme) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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a(CHEBI:heme) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

More recently, we have also shown that free heme is also released during storage and may mediate further inflammation28 PubMed:26202471

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a(CHEBI:heme) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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a(CHEBI:heme) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

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a(CHEBI:nitrite) negativeCorrelation a(HM:"stored erythrocytes") View Subject | View Object

We have also shown that older RBCs oxidize nitrite with faster rates compared to younger RBCs, which may account for decreased circulating nitrite levels in trauma patients receiving older RBCs14. PubMed:26202471

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Introduction

a(CHEBI:methemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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a(CHEBI:methemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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a(CHEBI:oxyhemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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a(CHEBI:oxyhemoglobin) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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bp(GO:"nitric oxide mediated signal transduction") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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bp(MESH:"Bacterial Load") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

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bp(MESH:"Oxidative Stress") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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p(MGI:Prdx2) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figure 2G shows storage also resulted in a significant increase in Prx-2 oxidation. PubMed:26202471

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p(MGI:Prdx2) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

The higher the basal (d7) level of Prx-2 oxidation, the higher the level of Prx-2 oxidation in the same RBC after 35 days of storage. PubMed:26202471

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p(MGI:"Hbb-b1") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

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p(MGI:Hmgb1) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

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p(MGI:Prdx2, pmod(Ox)) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

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Cell Ontology (CL)
erythrocyte
Text Location
Results

path(MESH:"Acute Lung Injury") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Moreover, longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis [63]. PubMed:29956069

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Cell Ontology (CL)
hepatocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:"Pulmonary Edema") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

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path(MESH:"Pulmonary Edema") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

TH and resuscitation with stored compared to fresh RBCs not only caused increased mortality but also significantly increased the severity of pulmonary edema induced by P. aeruginosa pneumonia (Fig 1D). PubMed:29522519

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path(MESH:Hemolysis) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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Discussion

path(MESH:Infection) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

The postoperative infection rate was significantly higher in children receiving the oldest blood (third tertile, 25-38 days) compared to those receiving the freshest RBCs (first tertile, 7-15 days) (34% vs. 7%; p50.004). PubMed:29603246

Appears in Networks:
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MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:Inflammation) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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Discussion

path(MESH:Pneumonia) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Our findings using a mouse model of trauma and hemorrhagic shock with stored blood transfusion and subsequent PAK instillation demonstrate that transfusion with older stored RBCs increases the severity of bacterial pneumonia. PubMed:29522519

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Cell Ontology (CL)
macrophage
Text Location
Discussion

path(MESH:Thrombosis) association a(HM:"stored erythrocytes") View Subject | View Object

Furthermore, retrospective studies suggest an association between transfusion of older, stored RBCs and thrombosis (Spinella et al, 2009). PubMed:25307023

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Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 43

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Figure 1B presents these data and shows that (i) basal (time 0) Prx-2 oxidation was higher at day 35 relative to day 14 and 28 ( p < 0.05 by one-way analysis of variance (ANOVA) with Tukey post hoc test); (ii) H2O2 significantly increased Prx-2 oxidation, which was maximal at the first time point (5 min) measured; (iii) the magnitude of the maximal level of Prx-2 oxidation increased with RBC storage age ( p < 0.05 by one-way ANOVA with Tukey post hoc test for day 7 vs. 35 for 5 min data); and (iv) dimeric Prx-2 was slowly reduced back to the monomer over 60 min; however, this was not observed with day 35 RBC, where Prx- 2 remained > 75% oxidized. PubMed:25264713

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Cell Ontology (CL)
erythrocyte
Text Location
Results

a(HM:"stored erythrocytes") causesNoChange p(MGI:Txn1) View Subject | View Object

However, no differences in basal Trx-reductase activities, Trx protein levels, or NADPH levels were observed in day 7 versus 35 RBC (Fig. 2), suggesting that this was not the basis of differential Prx-2 reduction kinetics. PubMed:25264713

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erythrocyte
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a(HM:"stored erythrocytes") causesNoChange a(CHEBI:NADPH) View Subject | View Object

However, no differences in basal Trx-reductase activities, Trx protein levels, or NADPH levels were observed in day 7 versus 35 RBC (Fig. 2), suggesting that this was not the basis of differential Prx-2 reduction kinetics. PubMed:25264713

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Cell Ontology (CL)
erythrocyte
Text Location
Results

a(HM:"stored erythrocytes") association path(MESH:Thrombosis) View Subject | View Object

Furthermore, retrospective studies suggest an association between transfusion of older, stored RBCs and thrombosis (Spinella et al, 2009). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(HM:"stored erythrocytes") negativeCorrelation a(CHEBI:nitrite) View Subject | View Object

We have also shown that older RBCs oxidize nitrite with faster rates compared to younger RBCs, which may account for decreased circulating nitrite levels in trauma patients receiving older RBCs14. PubMed:26202471

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Text Location
Introduction

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:oxyhemoglobin) View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:oxyhemoglobin) View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:methemoglobin) View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

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Annotations
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:methemoglobin) View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471

Appears in Networks:
Annotations
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:heme) View Subject | View Object

More recently, we have also shown that free heme is also released during storage and may mediate further inflammation28 PubMed:26202471

Appears in Networks:
Annotations
Text Location
Discussion

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

Appears in Networks:
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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Prdx2) View Subject | View Object

Figure 2G shows storage also resulted in a significant increase in Prx-2 oxidation. PubMed:26202471

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Prdx2) View Subject | View Object

The higher the basal (d7) level of Prx-2 oxidation, the higher the level of Prx-2 oxidation in the same RBC after 35 days of storage. PubMed:26202471

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Discussion

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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a(HM:"stored erythrocytes") increases path(MESH:Hemolysis) View Subject | View Object

The stored RBCs had approximately 7 times the hemolysis of fresh blood. PubMed:27308950

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MeSH
Endothelium, Vascular
Text Location
Introduction

a(HM:"stored erythrocytes") increases path(MESH:Hemolysis) View Subject | View Object

Any increase in hemolysis after transfusion of stored RBCs can be attributed to lysis of RBCs during storage or after transfusion (Figure 1B). PubMed:27308950

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MeSH
Plasma
Text Location
Discussion

a(HM:"stored erythrocytes") increases path(MESH:Hemolysis) View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

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Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") positiveCorrelation bp(GO:"nitric oxide mediated signal transduction") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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Discussion

a(HM:"stored erythrocytes") positiveCorrelation bp(MESH:"Oxidative Stress") View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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Discussion

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:Inflammation) View Subject | View Object

Storage is known to result in increased hemolysis which in turn results in loss of NO-signaling, oxidative stress and inflammation post-transfusion. PubMed:26202471

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Discussion

a(HM:"stored erythrocytes") decreases a(MESH:Dilatation) View Subject | View Object

In humans, infusion of RBCs stored for longer durations has been shown to significantly reduce brachial artery flow-mediated dilation12 and acetylcholine-stimulated forearm blood flow compared with fresher blood.19,20 PubMed:27308950

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MeSH
Arteries
Text Location
Introduction

a(HM:"stored erythrocytes") increases p(HGNC:HBB) View Subject | View Object

In the current observational study in patients undergoing multilevel spinal fusion surgery, we tested the hypothesis that moderate doses of stored RBC transfusions increase intravascular cell-free Hb and decrease NO availability in surgical patients. PubMed:27308950

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MeSH
Endothelium, Vascular
Text Location
Introduction

a(HM:"stored erythrocytes") decreases a(CHEBI:"nitric oxide") View Subject | View Object

In the current observational study in patients undergoing multilevel spinal fusion surgery, we tested the hypothesis that moderate doses of stored RBC transfusions increase intravascular cell-free Hb and decrease NO availability in surgical patients. PubMed:27308950

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Annotations
MeSH
Endothelium, Vascular
Text Location
Introduction

a(HM:"stored erythrocytes") decreases a(CHEBI:"nitric oxide") View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") decreases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Stored RBCs exhibit altered biophysical characteristics, including higher cell rigidity that accounts in part for impaired blood flow hemodynamics and adverse effects of RBC transfusion [26]. PubMed:28458720

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MeSH
Veins
Text Location
Review

a(HM:"stored erythrocytes") increases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

For example, Hb and subsequently, hemin accumulate during storage of human blood as RBC membrane integrity decreases [4]. PubMed:30281034

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Cell Ontology (CL)
erythrocyte
Text Location
Review

a(HM:"stored erythrocytes") decreases bp(MESH:Hemodynamics) View Subject | View Object

Stored RBCs exhibit altered biophysical characteristics, including higher cell rigidity that accounts in part for impaired blood flow hemodynamics and adverse effects of RBC transfusion [26]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

a(HM:"stored erythrocytes") increases a(MESH:Lysophospholipids) View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") increases a(CHEBI:"iron(2+)") View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

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Results

a(HM:"stored erythrocytes") increases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") increases a(MESH:"Cell-Derived Microparticles") View Subject | View Object

Stored RBCs undergo a complex structural and metabolic impairment that includes leakage of hemoglobin from the cells and hemolysis, reduced energy and NO production, formation of toxic products, such as lysophospholipids and free iron, phosphatidylserine exposure and shedding MPs [59]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(HM:"stored erythrocytes") increases a(MESH:Mortality) View Subject | View Object

However, mortality significantly increased in mice resuscitated with stored RBCs (median survival 8 h, n = 9), with all mice dying within 20 h of PAK instillation (Fig 1C). PubMed:29522519

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a(HM:"stored erythrocytes") positiveCorrelation path(MESH:"Pulmonary Edema") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:"Pulmonary Edema") View Subject | View Object

TH and resuscitation with stored compared to fresh RBCs not only caused increased mortality but also significantly increased the severity of pulmonary edema induced by P. aeruginosa pneumonia (Fig 1D). PubMed:29522519

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Results

a(HM:"stored erythrocytes") positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

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Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:"Hbb-b1") View Subject | View Object

Fig 2 shows that free hemoglobin and free heme were higher 4 h after resuscitation with stored RBCs compared to fresh RBCs (n = 3±7 as indicated); NTBI level was also higher, but this difference did not reach statistical significance (p = 0.07). PubMed:29522519

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Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

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Results

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:Pneumonia) View Subject | View Object

Our findings using a mouse model of trauma and hemorrhagic shock with stored blood transfusion and subsequent PAK instillation demonstrate that transfusion with older stored RBCs increases the severity of bacterial pneumonia. PubMed:29522519

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Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:Infection) View Subject | View Object

The postoperative infection rate was significantly higher in children receiving the oldest blood (third tertile, 25-38 days) compared to those receiving the freshest RBCs (first tertile, 7-15 days) (34% vs. 7%; p50.004). PubMed:29603246

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation path(MESH:"Acute Lung Injury") View Subject | View Object

Moreover, longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis [63]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.