Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(HM:"stored erythrocytes") increases a(MESH:Mortality) View Subject | View Object

However, mortality significantly increased in mice resuscitated with stored RBCs (median survival 8 h, n = 9), with all mice dying within 20 h of PAK instillation (Fig 1C). PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation a(MESH:Mortality) View Subject | View Object

After resuscitation with SRBCs, only 58% of mice survived for 48 hours (SRBC vs. FRBC, P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation a(MESH:Mortality) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) negativeCorrelation a(MESH:Mortality) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

p(HGNC:HP) negativeCorrelation a(MESH:Mortality) View Subject | View Object

Increased circulating cell-free Hb, heme, and iron and decreased haptoglobin concentrations have been associated with morbidity and mortality in both animal models and patients.4,5 PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation a(MESH:Mortality) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:Anemia) positiveCorrelation a(MESH:Mortality) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 6

a(MESH:Mortality) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

After resuscitation with SRBCs, only 58% of mice survived for 48 hours (SRBC vs. FRBC, P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:Mortality) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:Mortality) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:Mortality) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

a(MESH:Mortality) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:Mortality) negativeCorrelation p(HGNC:HP) View Subject | View Object

Increased circulating cell-free Hb, heme, and iron and decreased haptoglobin concentrations have been associated with morbidity and mortality in both animal models and patients.4,5 PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.