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p(MGI:Hmgb1)

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Entity

Name
Hmgb1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:heme) positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

Furthermore, free heme also induced extracellular release of HMGB1 from RMVECs compared to vehicle control (Fig 5B). PubMed:29522519

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a(CHEBI:heme) positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

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Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation p(MGI:Hmgb1) View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

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Text Location
Results

Out-Edges 4

p(MGI:Hmgb1) positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Fig 5A shows that extracellular serum levels of HMGB1 were approximately 5-fold higher in mice (n = 3) resuscitated with stored RBCs compared to mice resuscitated fresh RBCs. PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

p(MGI:Hmgb1) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Furthermore, free heme also induced extracellular release of HMGB1 from RMVECs compared to vehicle control (Fig 5B). PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

p(MGI:Hmgb1) positiveCorrelation a(CHEBI:heme) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

p(MGI:Hmgb1) decreases bp(GO:phagocytosis) View Subject | View Object

In summary, these results indicate that heme from resuscitation with stored RBCs increases extracellular release of HMGB1, which inhibits macrophage phagocytosis of P. aeruginosa, leading to increased mortality. PubMed:29522519

Appears in Networks:
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Cell Ontology (CL)
macrophage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.