a(CHEBI:oxyhemoglobin)
Figures 5C-5D show that d7 propagation rates for nitrite oxidation correlate with both d7 and d35 cell-free oxyhemoglobin. PubMed:26202471
Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471
Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519
For example, autooxidation of oxyhemoglobin (HbO2) or oxymyoglobin (MbO2) produces met-Hb or met-Mb, respectively, and superoxide radicals (O2•−, HO2•) via electron transfer [3,4]. PubMed:24486321
Figures 2A-F show changes in oxyhemoglobin, methemoglobin and free heme in both the intraerythrocytic and supernatant fractions in both d7 and d35 RBC. Significant storage-dependent increases for all species in the cell-free fraction were observed, with no storage-dependent differences observed in the erythrocyte. PubMed:26202471
Consistent with our previous studies [25,36], free oxyHb, metHb, and heme levels were increased after 14 d of RBC storage, being 930 ± 125 μM, 40.3 ± 8.8 μM, and 168 ± 44.7 μM, respectively (mean ± SEM, n = 7). PubMed:29522519
Figures 5C-5D show that d7 propagation rates for nitrite oxidation correlate with both d7 and d35 cell-free oxyhemoglobin. PubMed:26202471
In contrast, less ATP depletion was observed during exposure to heme-albumin, and no effect could be detected when either cell type was exposed to metHb or oxyHb at concentrations of up to 500 lmolL1, even in the absence of serum. PubMed:29610666
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.