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path(MESH:Anemia)

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Entity

Name
Anemia
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 14

a(CHEBI:"lead nitrate") positiveCorrelation path(MESH:Anemia) View Subject | View Object

In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909

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a(MESH:Morbidity) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

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a(MESH:Mortality) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

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a(MESH:Mortality) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

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bp(MESH:"Erythrocyte Count") negativeCorrelation path(MESH:Anemia) View Subject | View Object

The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

bp(MESH:Eryptosis) association path(MESH:Anemia) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

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Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

p(HGNC:HBB) negativeCorrelation path(MESH:Anemia) View Subject | View Object

The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953

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Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

p(MGI:Eif2ak1) negativeCorrelation path(MESH:Anemia) View Subject | View Object

Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

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Abstract

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

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path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P  0.05} (28). PubMed:29351418

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path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418

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MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(MESH:"Hematopoiesis, Extramedullary") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Extramedullary erythropoiesis is often switched on upon anemia, as characterized by splenomegaly.31 PubMed:25411909

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Cell Ontology (CL)
erythrocyte
MeSH
Bone Marrow
Text Location
Results

path(MESH:Stroke) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

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Introduction

Out-Edges 30

path(MESH:Anemia) negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

path(MESH:Anemia) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909

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Text Location
Results

path(MESH:Anemia) positiveCorrelation path(MESH:"Hematopoiesis, Extramedullary") View Subject | View Object

Extramedullary erythropoiesis is often switched on upon anemia, as characterized by splenomegaly.31 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Bone Marrow
Text Location
Results

path(MESH:Anemia) negativeCorrelation p(HGNC:HBB) View Subject | View Object

The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:Anemia) decreases p(HGNC:HBB) View Subject | View Object

By day 1 following injection, plasma Hb concentrations in the anemia group were reduced to 0.5  0.3 g/l, which was not significantly different from the control value of 0.5  0.3 g/l (n  6, unadjusted P  0.93; Fig. 3A). PubMed:29351418

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MeSH
Plasma
Text Location
Results

path(MESH:Anemia) negativeCorrelation bp(MESH:"Erythrocyte Count") View Subject | View Object

The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:Anemia) positiveCorrelation a(MESH:Mortality) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:Anemia) positiveCorrelation a(MESH:Mortality) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation a(MESH:Morbidity) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P  0.05} (28). PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(MESH:Anemia) positiveCorrelation path(MESH:Stroke) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

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Introduction

path(MESH:Anemia) increases a(MESH:"Blood Gas Monitoring, Transcutaneous") View Subject | View Object

SpO2 values increased in anemic mice (n  6) from a baseline value of 97.1  0.6% to a day 3 value of 98.1  0.2 and a day 4 value of 97.8  0.4% (n  6, unadjusted P  0.02, adjusted P  0.05; Fig. 4). Day 4 SpO2 values were higher than a control value of 97.0  0.8% (n  6; unadjusted P  0.01, adjusted P  0.05). PubMed:29351418

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MeSH
Plasma
Text Location
Results

path(MESH:Anemia) increases act(a(MESH:"Carotid Artery, Internal")) View Subject | View Object

Internal carotid artery flow increased from a baseline value of 0.3  0.1 ml/min to 0.6  0.1 ml/min during anemia (unadjusted P  0.001, adjusted P  0.001; Fig. 5). PubMed:29351418

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MeSH
Plasma
Text Location
Results

path(MESH:Anemia) decreases a(MESH:"Partial Pressure") View Subject | View Object

During anemia, kidney PtO2 was reduced to a value of 13.1  4.3 mmHg (n  10) compared with a control value of 20.8  3.7 mmHg (n  14; P  0.001; Fig. 6). PubMed:29351418

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MeSH
Kidney
Text Location
Results

path(MESH:Anemia) causesNoChange a(MESH:"Partial Pressure") View Subject | View Object

Brain PtO2 of anemic mice was 22.7  5.2 mmHg (n  13), which was not significantly different from a control value of 23.4  9.8 mmHg (n  14, P  0.59). PubMed:29351418

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MeSH
Brain
Text Location
Results

path(MESH:Anemia) increases complex(a(MESH:Luciferases), p(MGI:Hif1a)) View Subject | View Object

D). “Right kidney  liver region” HIF/luciferase radiance increased from a baseline value of 5.30 107  1.23 107 p/s to a day 4 value of 6.72 107  1.63 107 p/s (unadjusted P  0.01, adjusted P  0.04; Fig. 7E). PubMed:29351418

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MeSH
Kidney
MeSH
Liver
Text Location
Results

path(MESH:Anemia) increases complex(a(MESH:Luciferases), p(MGI:Hif1a)) View Subject | View Object

“Gut region” HIF/luciferase radiance at the day 4 time point was 4.38 108  4.00 108 p/s, which was higher than a control value of 2.36 108  0.93 108 p/s (unadjusted P  0.001, adjusted P  0.001; Fig. 8E). PubMed:29351418

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MeSH
Kidney
MeSH
Liver
Text Location
Results

path(MESH:Anemia) increases complex(a(MESH:Luciferases), p(MGI:Hif1a)) View Subject | View Object

In addition, change in day 4 gut region HIF/luciferase radiance values from baseline in anemic mice was 1.68 108  3.48 108 p/s, which was higher than a control value of 1.08 108  1.28 108 p/s (P  0.02). PubMed:29351418

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MeSH
Kidney
MeSH
Liver
Text Location
Results

path(MESH:Anemia) increases act(r(MGI:Epo), ma(tscript)) View Subject | View Object

During anemia (n  6), kidney EPO mRNA transcription increased 20-fold relative to control mice (n  5, P  0.001; Fig. 9A). PubMed:29351418

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MeSH
Kidney
Text Location
Results

path(MESH:Anemia) causesNoChange act(r(MGI:Epo), ma(tscript)) View Subject | View Object

Heart EPO mRNA transcription was not significantly different in anemic mice relative to control mice (P  0.35). PubMed:29351418

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MeSH
Heart
Text Location
Results

path(MESH:Anemia) increases r(MGI:Epo) View Subject | View Object

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418

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MeSH
Brain
MeSH
Anemia
Text Location
Discussion

path(MESH:Anemia) increases r(MGI:Hmox1) View Subject | View Object

Brain HO-1 mRNA levels increased by 38% in anemic mice relative to control mice (P  0.01), and GAPDH mRNA levels increased by 18% in anemic mice relative to control mice (P  0.002; Fig. 9B). PubMed:29351418

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MeSH
Brain
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Results

path(MESH:Anemia) increases r(MGI:Hmox1) View Subject | View Object

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418

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MeSH
Brain
MeSH
Anemia
Text Location
Discussion

path(MESH:Anemia) increases r(MGI:Gapdh) View Subject | View Object

Brain HO-1 mRNA levels increased by 38% in anemic mice relative to control mice (P  0.01), and GAPDH mRNA levels increased by 18% in anemic mice relative to control mice (P  0.002; Fig. 9B). PubMed:29351418

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MeSH
Brain
Text Location
Results

path(MESH:Anemia) increases r(MGI:Gapdh) View Subject | View Object

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Anemia
Text Location
Discussion

path(MESH:Anemia) increases path(MESH:Hypoxia) View Subject | View Object

Our experimental data provided clear evidence that moderate subacute anemia resulted in a profound level of renal tissue hypoxia, as characterized by a reduction in kidney PtO2, an increase in regional HIF/luciferase radiance in vivo, and a substantial increase in EPO mRNA level at a Hb concentration consistent with moderate anemia (90 g/l). PubMed:29351418

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MeSH
Kidney
Text Location
Discussion

path(MESH:Anemia) association bp(MESH:Eryptosis) View Subject | View Object

On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

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