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p(MGI:Eif2ak1)

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Entity

Name
Eif2ak1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

bp(GO:"cell death") negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

Moreover, in the current study, we identified a crucial role of Hri in protecting erythroid precursors during differentiation by promoting terminal maturation including enucleation, preventing cell death, and increasing iron availability for erythropoiesis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

bp(GO:"erythrocyte apoptotic process") negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

These data suggested that Pb-induced anemia should be ascribed to (at least partially) Pbinduced death of erythrocytes, and also stressed the critical role of Hri in assuring the survival of BM and spleen erythroid cells under Pb exposure. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte apoptotic process") negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

Hri is activated to protect cells from oxidative stress-provoked apoptosis upon arsenic, cadmium, and iron deficiency.18,19,22 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

bp(GO:"erythrocyte differentiation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

These findings together led us to postulate that there could be disordered differentiation and survival for Hri-deficient erythroid cells upon Pb exposure. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte differentiation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

These results are similar to our findings in an earlier study where Hri deficiency resulted in the blockade of erythroid differentiation of FL cells from early and late basophilic erythroblasts into chromatophilic and orthochromatophilic erythroblasts.19 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte differentiation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

These results suggest that Pb elicits direct inhibition of erythroid cell differentiation and that more importantly Hri takes a crucial role in promoting erythroid differentiation in response to Pb-induced toxicity. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte differentiation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

These data together demonstrated that Pb caused the inhibition of erythroid enucleation and that Hri seemingly surveilled the terminal differentiation of erythroblasts for appropriate hemoglobin production and final maturation before enucleation. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte differentiation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

Our combined results revealed that Hri functions to protect erythroid cells from Pb-induced toxicity through enhancing erythroid differentiation, enforcing cell survival, and orchestrating iron homeostasis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

bp(GO:"erythrocyte enucleation") positiveCorrelation p(MGI:Eif2ak1) View Subject | View Object

Moreover, in the current study, we identified a crucial role of Hri in protecting erythroid precursors during differentiation by promoting terminal maturation including enucleation, preventing cell death, and increasing iron availability for erythropoiesis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Hamp) negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

Moreover, loss of Hri gave rise to hepatic hepcidin induction, associated with iron retention in spleens. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Spleen
Text Location
Discussion

path(MESH:Anemia) negativeCorrelation p(MGI:Eif2ak1) View Subject | View Object

Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

Out-Edges 11

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

These findings together led us to postulate that there could be disordered differentiation and survival for Hri-deficient erythroid cells upon Pb exposure. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

These results are similar to our findings in an earlier study where Hri deficiency resulted in the blockade of erythroid differentiation of FL cells from early and late basophilic erythroblasts into chromatophilic and orthochromatophilic erythroblasts.19 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

These results suggest that Pb elicits direct inhibition of erythroid cell differentiation and that more importantly Hri takes a crucial role in promoting erythroid differentiation in response to Pb-induced toxicity. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

These data together demonstrated that Pb caused the inhibition of erythroid enucleation and that Hri seemingly surveilled the terminal differentiation of erythroblasts for appropriate hemoglobin production and final maturation before enucleation. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

Our combined results revealed that Hri functions to protect erythroid cells from Pb-induced toxicity through enhancing erythroid differentiation, enforcing cell survival, and orchestrating iron homeostasis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Eif2ak1) negativeCorrelation bp(GO:"erythrocyte apoptotic process") View Subject | View Object

These data suggested that Pb-induced anemia should be ascribed to (at least partially) Pbinduced death of erythrocytes, and also stressed the critical role of Hri in assuring the survival of BM and spleen erythroid cells under Pb exposure. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

p(MGI:Eif2ak1) negativeCorrelation bp(GO:"erythrocyte apoptotic process") View Subject | View Object

Hri is activated to protect cells from oxidative stress-provoked apoptosis upon arsenic, cadmium, and iron deficiency.18,19,22 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Eif2ak1) negativeCorrelation path(MESH:Anemia) View Subject | View Object

Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Eif2ak1) positiveCorrelation bp(GO:"erythrocyte enucleation") View Subject | View Object

Moreover, in the current study, we identified a crucial role of Hri in protecting erythroid precursors during differentiation by promoting terminal maturation including enucleation, preventing cell death, and increasing iron availability for erythropoiesis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Eif2ak1) negativeCorrelation bp(GO:"cell death") View Subject | View Object

Moreover, in the current study, we identified a crucial role of Hri in protecting erythroid precursors during differentiation by promoting terminal maturation including enucleation, preventing cell death, and increasing iron availability for erythropoiesis. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

p(MGI:Eif2ak1) negativeCorrelation p(MGI:Hamp) View Subject | View Object

Moreover, loss of Hri gave rise to hepatic hepcidin induction, associated with iron retention in spleens. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Spleen
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.