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path(MESH:Stroke)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Stroke
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 2

The role of inflammasome in Alzheimer’s disease v1.0.3

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(MESH:"Blood Transfusion") negativeCorrelation path(MESH:Stroke) View Subject | View Object

Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
Text Location
Review

p(HGNC:CD59, var("p.Cys89Tyr")) increases path(MESH:Stroke) View Subject | View Object

Nonfunctioning CD59 is a major risk factor for stroke and hypercoagulability. PubMed:29929138

Appears in Networks:
Annotations
Text Location
Abstract

p(HGNC:CD59, var("p.Cys89Tyr")) positiveCorrelation path(MESH:Stroke) View Subject | View Object

More recently, we have described two infants carrying the mutation who manifested with recurrent strokes [8], establishing the concept that primary Cys89Tyr mutation in CD59 leads to a thrombophilic state. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

p(HGNC:CD59, var("p.Cys89Tyr")) increases path(MESH:Stroke) View Subject | View Object

We recently encountered patients with recurrent strokes leading to premature death in 2/7 young children with primary Cys89Tyr CD59 deficiency [8]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Coronary Vessels
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(MESH:Anemia) positiveCorrelation path(MESH:Stroke) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 4

path(MESH:Stroke) increases complex(GO:"inflammasome complex") View Subject | View Object

Furthermore, postmortem brain tissues from stroke patients show increase protein levels of inflammasomes in primary cortical neurons (Yang- Wei Fann et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

path(MESH:Stroke) negativeCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
Text Location
Review

path(MESH:Stroke) positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Stroke) positiveCorrelation p(HGNC:CD59, var("p.Cys89Tyr")) View Subject | View Object

More recently, we have described two infants carrying the mutation who manifested with recurrent strokes [8], establishing the concept that primary Cys89Tyr mutation in CD59 leads to a thrombophilic state. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.