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path(MESH:"Acute Kidney Injury")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Acute Kidney Injury
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

a(CHEBI:heme) increases path(MESH:"Acute Kidney Injury") View Subject | View Object

Heme may be implicated and contribute to the development of (i) bp(MESH: PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Anemia, Sickle Cell
Text Location
Review

p(MGI:Hp) decreases path(MESH:"Acute Kidney Injury") View Subject | View Object

By binding cell-free hemoglobin, haptoglobin prevents glomerular filtration of cell-free hemoglobin and subsequent kidney injury (2,7). PubMed:28314763

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Text Location
Introduction

p(MGI:Hmox1) negativeCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

For instance, Hmox−/− mice develops acute renal failure and marked mortality when submitted to rhabdomyolysis, a pathological condition that increases serum myoglobin which can be oxidized and release heme (Nath et al., 2000). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Rhabdomyolysis
Text Location
Review

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

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Annotations
Text Location
Abstract

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P  0.05} (28). PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Anemia) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(MESH:Hemoglobinuria) association path(MESH:"Acute Kidney Injury") View Subject | View Object

Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Acute Kidney Injury") View Subject | View Object

Therefore, acute kidney injury (AKI) remains an important complication of acute and severe intravascular hemolysis. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

Out-Edges 7

path(MESH:"Acute Kidney Injury") negativeCorrelation p(MGI:Hmox1) View Subject | View Object

For instance, Hmox−/− mice develops acute renal failure and marked mortality when submitted to rhabdomyolysis, a pathological condition that increases serum myoglobin which can be oxidized and release heme (Nath et al., 2000). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Rhabdomyolysis
Text Location
Review

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Therefore, acute kidney injury (AKI) remains an important complication of acute and severe intravascular hemolysis. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

path(MESH:"Acute Kidney Injury") association path(MESH:Hemoglobinuria) View Subject | View Object

Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P  0.05} (28). PubMed:29351418

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Acute Kidney Injury") positiveCorrelation path(MESH:Anemia) View Subject | View Object

In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.