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a(CHEBI:"carbon monoxide")

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Entity

Name
carbon monoxide
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 14

act(a(CHEBI:antioxidant)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

deg(a(CHEBI:heme)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Within cells, heme is catabolized by the activity of heme oxygenases (inducible HO-1 and constitutive HO-2) into iron, carbon monoxide, and biliverdin. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(HM:Thrombus) negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

bp(GO:"heme catabolic process") increases a(CHEBI:"carbon monoxide") View Subject | View Object

Once inside the cells, heme is catabolized by HO enzymes, generating equimolar amounts of biliverdin, carbon monoxide (CO), and Fe (Tenhunen et al., 1968). PubMed:24904418

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Annotations
Text Location
Review

complex(a(CHEBI:"carbon monoxide"), a(CHEBI:heme), p(HGNC:FGA)) hasComponent a(CHEBI:"carbon monoxide") View Subject | View Object

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complex(a(CHEBI:"carbon monoxide"), a(CHEBI:"iron(2+)"), a(CHEBI:biliverdin)) hasComponent a(CHEBI:"carbon monoxide") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"carbon monoxide"), p(HGNC:HBB)) hasComponent a(CHEBI:"carbon monoxide") View Subject | View Object

Appears in Networks:

act(p(MGI:Hpx)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

The beneficial effects of Hp and Hpx were lost by inhibition of HO with SnPP, but could be restored by CO administration. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

act(p(MGI:Hp)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

The beneficial effects of Hp and Hpx were lost by inhibition of HO with SnPP, but could be restored by CO administration. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(MGI:Hmox1) increases a(CHEBI:"carbon monoxide") View Subject | View Object

Moreover, mitochondrial translocation of HO-1 can also lead to localized CO production as a result of heme degradation, thus inhibiting electron flow though mitochondrial electron transport chain complex IV (44). PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

act(p(MGI:Nfkb1)) negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Prdx2, pmod(Ox)) positiveCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Figure 5C shows that pretreatment of human RBC stored for 35 days with CO, or CO-added 5 min after H2O2, significantly accelerated Prx-2 reduction from the dimer to monomer (by *35% relative to control at 20 min). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:"Vascular System Injuries") negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

By-products of heme and iron metabolism, such as heme oxygenase-dependent generation of carbon monoxide (CO), have antioxidant and anti-inflammatory protective functions against iron-induced vascular damage (33); therefore we examined the impact of CO donors on collagen exposure and thrombus formation in the ex vivo vascular injury model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

Out-Edges 17

a(CHEBI:"carbon monoxide") increases bp(MESH:Vasodilation) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"carbon monoxide") positiveCorrelation p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Figure 5C shows that pretreatment of human RBC stored for 35 days with CO, or CO-added 5 min after H2O2, significantly accelerated Prx-2 reduction from the dimer to monomer (by *35% relative to control at 20 min). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(CHEBI:"carbon monoxide") negativeCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

By-products of heme and iron metabolism, such as heme oxygenase-dependent generation of carbon monoxide (CO), have antioxidant and anti-inflammatory protective functions against iron-induced vascular damage (33); therefore we examined the impact of CO donors on collagen exposure and thrombus formation in the ex vivo vascular injury model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"carbon monoxide") negativeCorrelation a(HM:Thrombus) View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"carbon monoxide") decreases bp(GO:"inflammatory response") View Subject | View Object

Differently from biliverdin and CO, which have anti-inflammatory effects (Otterbein et al., 2000; Baranano et al., 2002), free Fe is highly oxidative and can promote free radicals generation through the Fenton reaction, which catalyzes hydroxyl radicals from the reaction of Fe with H2O2 (Fenton, 1894). PubMed:24904418

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Annotations
Text Location
Review

a(CHEBI:"carbon monoxide") decreases a(CHEBI:heme) View Subject | View Object

CO inhibits Hb oxidation and subsequently heme release, thus blocking heme accumulation in serum and preventing heme from exerting its inflammatory effects in the course of malaria disease (Ferreira et al., 2011). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:"carbon monoxide") positiveCorrelation deg(a(CHEBI:heme)) View Subject | View Object

Within cells, heme is catabolized by the activity of heme oxygenases (inducible HO-1 and constitutive HO-2) into iron, carbon monoxide, and biliverdin. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(CHEBI:"carbon monoxide") decreases p(MGI:Prdx2, pmod(Ox)) View Subject | View Object

Presaturation of RBC with CO affected neither initial H2O2- dependent Prx-2 oxidation nor Prx-2 reduction in either RBC, although a trend toward decreased Prx-2 oxidation over 5 min was noted in CO-treated cells ( p = 0.08 between with and without CO groups for b93Cys RBC). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

a(CHEBI:"carbon monoxide") increases bp(MESH:Vasodilation) View Subject | View Object

This could be explained by the finding that CO induces vasodilation by binding to the heme-protein guanylyl cyclase [67]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

a(CHEBI:"carbon monoxide") decreases bp(GO:"cell proliferation") View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"carbon monoxide") decreases path(MESH:Inflammation) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"carbon monoxide") positiveCorrelation act(a(CHEBI:antioxidant)) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"carbon monoxide") decreases complex(a(GO:"mitochondrial respiratory chain complex IV")) View Subject | View Object

Moreover, mitochondrial translocation of HO-1 can also lead to localized CO production as a result of heme degradation, thus inhibiting electron flow though mitochondrial electron transport chain complex IV (44). PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

a(CHEBI:"carbon monoxide") negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:"carbon monoxide") negativeCorrelation act(p(MGI:Nfkb1)) View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:"carbon monoxide") positiveCorrelation act(p(MGI:Hp)) View Subject | View Object

The beneficial effects of Hp and Hpx were lost by inhibition of HO with SnPP, but could be restored by CO administration. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

a(CHEBI:"carbon monoxide") positiveCorrelation act(p(MGI:Hpx)) View Subject | View Object

The beneficial effects of Hp and Hpx were lost by inhibition of HO with SnPP, but could be restored by CO administration. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.