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path(HM:"vaso-occlusive crisis")

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Entity

Name
vaso-occlusive crisis
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 22

a(CHEBI:"carbon monoxide") negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:heme) increases path(HM:"vaso-occlusive crisis") View Subject | View Object

For example, one of the severe complications of sickle-cell disease is vaso-occlusion, an outcome that can be triggered in mice upon heme administration [27,32]. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) increases path(HM:"vaso-occlusive crisis") View Subject | View Object

Heme is one of the factors capable of inducing stimulation and damage of endothelium, promoting the recruitment of neutrophils and sickle-cell erythro- cytes, and subsequently prompting a vaso-occlusive crisis. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) increases path(HM:"vaso-occlusive crisis") View Subject | View Object

Heme may be implicated and contribute to the development of (i) bp(MESH: PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(CHEBI:heme) increases path(HM:"vaso-occlusive crisis") View Subject | View Object

Administration of heme in healthy volunteers caused thrombophlebitis, demonstrating that it can cause vascular inflammation followed by vascular obstruction [18]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

a(CHEBI:heme) increases path(HM:"vaso-occlusive crisis") View Subject | View Object

Heme/TLR-4 signaling, moreover, was found to activate NF-κB and trigger vaso-occlusion [42]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

a(MESH:"Cell-Derived Microparticles") increases path(HM:"vaso-occlusive crisis") View Subject | View Object

The circulating MPs can internalize free heme and transfer it to vascular endothelium, promoting vaso-occlusion, or amplify systemic inflammation via thrombin mediated activation of the complement system [57]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

p(HGNC:HBB) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Infusion of exogenous hemoglobin into SS-mice can markedly increase stasis compared to the amount of spontaneous stasis [5]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hpx) decreases path(HM:"vaso-occlusive crisis") View Subject | View Object

These findings are consistent with a recent study which showed that both Hp and hemopexin (heme scavenger) were equally effective in preventing vasoocclusion in a sickle cell mouse model infused with Hb [73]. PubMed:24486321

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(MGI:Hpx) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hpx) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hpx) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hp) decreases path(HM:"vaso-occlusive crisis") View Subject | View Object

These findings are consistent with a recent study which showed that both Hp and hemopexin (heme scavenger) were equally effective in preventing vasoocclusion in a sickle cell mouse model infused with Hb [73]. PubMed:24486321

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(MGI:Hp) decreases path(HM:"vaso-occlusive crisis") View Subject | View Object

Likewise, 395 infusion of haptoglobin or hemopexin in HbS mice inhibited hemoglobin-dependent 396 vaso-occlusion (3). PubMed:28314763

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

p(MGI:Hp) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hp) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hp) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hmox1) negativeCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

We have previously shown that induction of HO-1 expression or liver-directed HO-1 gene therapy inhibits stasis in sickle mice exposed to H/R [38, 45]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:"Acute Chest Syndrome") positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Vaso-occlusion of the lung microvasculature may result in the development of the ACS through the infarction of the lung parenchyma. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:Hypoxia) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:Hypoxia) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

Out-Edges 13

path(HM:"vaso-occlusive crisis") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(HM:"vaso-occlusive crisis") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") positiveCorrelation path(MESH:"Acute Chest Syndrome") View Subject | View Object

Vaso-occlusion of the lung microvasculature may result in the development of the ACS through the infarction of the lung parenchyma. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(HM:"vaso-occlusive crisis") positiveCorrelation a(CHEBI:heme) View Subject | View Object

The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Introduction

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hp) View Subject | View Object

Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hp) View Subject | View Object

Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hp) View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hpx) View Subject | View Object

Thus a single infusion of Hp or Hpx inhibited stasis for 48h. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hpx) View Subject | View Object

Sickle mice co-infused with Hb + Hp, Hb + Hpx or Hb + Hp + Hpx had less stasis 1h after infusion than mice infused with Hb + albumin or Hb (Fig 1B). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hpx) View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Infusion of exogenous hemoglobin into SS-mice can markedly increase stasis compared to the amount of spontaneous stasis [5]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation p(MGI:Hmox1) View Subject | View Object

We have previously shown that induction of HO-1 expression or liver-directed HO-1 gene therapy inhibits stasis in sickle mice exposed to H/R [38, 45]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(HM:"vaso-occlusive crisis") negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

CO also inhibited stasis in mice treated with SnPP + Hb without Hp or Hpx. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

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