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a(HM:Thrombus)

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Entity

Name
Thrombus
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:"carbon monoxide") negativeCorrelation a(HM:Thrombus) View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation a(HM:Thrombus) View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

p(HGNC:ADAMTS13) decreases a(HM:Thrombus) View Subject | View Object

One mechanism that may contribute to enhanced platelet thrombus formation is inhibition of the metalloprotease ADAMTS13 by free hemoglobin [20]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(MGI:Gp6) positiveCorrelation a(HM:Thrombus) View Subject | View Object

Platelet thrombus formation in the ex vivo model occurred in the presence of hirudin (Fig. 1B); however, it was critically dependent on collagen activation of platelets as thrombus formation failed to develop using platelets deficient in the major collagen receptor GPVI/FcR -chain (FcR / mice) (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
Text Location
Introduction

Out-Edges 3

a(HM:Thrombus) positiveCorrelation p(MGI:Gp6) View Subject | View Object

Platelet thrombus formation in the ex vivo model occurred in the presence of hirudin (Fig. 1B); however, it was critically dependent on collagen activation of platelets as thrombus formation failed to develop using platelets deficient in the major collagen receptor GPVI/FcR -chain (FcR / mice) (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
Text Location
Introduction

a(HM:Thrombus) negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(HM:Thrombus) positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.