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Pre-Eclampsia

Name
Pre-Eclampsia
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:"carbon monoxide") increases bp(MESH:Vasodilation) View Subject | View Object

This could be explained by the finding that CO induces vasodilation by binding to the heme-protein guanylyl cyclase [67]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

a(CHEBI:heme) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

In line with previously published studies [13,14] the extravascular heme- and radical scavenger A1M was significantly increased in plasma of women with PE. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

a(MESH:"Fetal Hemoglobin") positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

A 4-fold increase of the HbF concentration was seen in the PE patients (p-value 0.01) as compared to the controls. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Placenta
MeSH
Pre-Eclampsia
Text Location
Results

a(MESH:"Fetal Hemoglobin") negativeCorrelation p(HGNC:HP) View Subject | View Object

A negative correlation was found, i.e. an increased plasma cell-free HbF concentration was associated with a decreased plasma Hp concentration, when including all individuals, controls and women with PE (r = -0.335, p-value<0.0001, n = 145)(Fig 1A). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

a(MESH:"haptoglobin-hemoglobin complex") positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Placenta
MeSH
Pre-Eclampsia
Text Location
Results

Showing 5 of 23 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.