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p(MGI:Nfkb1)

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Entity

Name
Nfkb1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 3

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) View Subject | View Object

Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 􏰆 0.78, binomial test). PubMed:29255009

Appears in Networks:

path(MESH:Aging) increases p(MGI:Nfkb1) View Subject | View Object

Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 􏰆 0.78, binomial test). PubMed:29255009

Appears in Networks:

a(CHEBI:"carbon monoxide") negativeCorrelation act(p(MGI:Nfkb1)) View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(HGNC:HBB) increases act(p(MGI:Nfkb1)) View Subject | View Object

We also found that HbFe21 and HbFe31 activate NF-kB and mitogen-activated protein kinase pathways, as shown by phosphorylation of NF-kB p65 subunit and p44/42, respectively (Figure E3) as noted previously (31). PubMed:26974230

Appears in Networks:
Annotations
MeSH
Alveolar Epithelial Cells
Text Location
Results

complex(a(CHEBI:"tin atom"), a(CHEBI:protoporphyrin)) negativeCorrelation act(p(MGI:Nfkb1)) View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hpx) negativeCorrelation act(p(MGI:Nfkb1)) View Subject | View Object

Compared to Hb alone or Hb + albumin infused animals, sickle mice co-infused with Hb + Hp, Hb + Hpx, or Hb + Hp + Hpx had markedly diminished hepatic NF-κB activation 4h after infusion as evidenced by nuclear NF- κB phospho-p65 levels (Fig 2A). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Alb) causesNoChange act(p(MGI:Nfkb1)) View Subject | View Object

In contrast, albumin did not induce HO-1 or inhibit stasis and NF- κB. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(MGI:Hp) negativeCorrelation act(p(MGI:Nfkb1)) View Subject | View Object

Compared to Hb alone or Hb + albumin infused animals, sickle mice co-infused with Hb + Hp, Hb + Hpx, or Hb + Hp + Hpx had markedly diminished hepatic NF-κB activation 4h after infusion as evidenced by nuclear NF- κB phospho-p65 levels (Fig 2A). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

Out-Edges 6

act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") View Subject | View Object

NFkB regulates the pro-survival, pro-inflammatory SASP gene expression profile characteristic of cellular senescence (Salminen & Kaarniranta, 2011) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

act(p(MGI:Nfkb1)) negativeCorrelation p(MGI:Hp) View Subject | View Object

Compared to Hb alone or Hb + albumin infused animals, sickle mice co-infused with Hb + Hp, Hb + Hpx, or Hb + Hp + Hpx had markedly diminished hepatic NF-κB activation 4h after infusion as evidenced by nuclear NF- κB phospho-p65 levels (Fig 2A). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

act(p(MGI:Nfkb1)) negativeCorrelation p(MGI:Hpx) View Subject | View Object

Compared to Hb alone or Hb + albumin infused animals, sickle mice co-infused with Hb + Hp, Hb + Hpx, or Hb + Hp + Hpx had markedly diminished hepatic NF-κB activation 4h after infusion as evidenced by nuclear NF- κB phospho-p65 levels (Fig 2A). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

act(p(MGI:Nfkb1)) negativeCorrelation a(CHEBI:"carbon monoxide") View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

act(p(MGI:Nfkb1)) negativeCorrelation complex(a(CHEBI:"tin atom"), a(CHEBI:protoporphyrin)) View Subject | View Object

SnPP and CO had similar inhibitory effects on NF-kB activation in the liver (data not shown). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.