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a(MESH:"Blood Transfusion")

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Entity

Name
Blood Transfusion
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 27

a(CHEBI:"4-hydroxynon-2-enal") positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Renal tissues from old blood-transfused animals exhibited 4-HNE-positive staining. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

In old blood-transfused animals, strong Hb and iron deposition was observed in the tubule lumen and epithelial cells, respectively. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney Tubules
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Tissue iron staining revealed greater cortical iron accumulation in the kidneys of mice resuscitated with SRBCs, SRBCs combined with albumin and SRBCs combined with hemopexin than in the kidneys of mice transfused with FRBCs (Figure 6A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Splenic iron content was greater in mice after resuscitation with SRBCs than in FRBC-transfused mice. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Taken together, these results indicate that haptoglobin co-transfusion prevented stored blood transfusion-associated renal iron uptake and led to increased weight and greater iron- accumulation in the spleens of mice. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

a(CHEBI:methemoglobin) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Electron paramagnetic resonance (EPR) spectra of renal tissues from old blood-transfused animals were recorded at 6K and showed a strong signal around g=6, which is indicative of high-spin ferric Hb(Fe3+) (Figure 3a). PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Results

a(CHEBI:methemoglobin) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

First, quantification of high-spin ferric Hb(Fe3+), which is the initial Hb oxidation product resulting from the oxidation of ferrous oxyHb(Fe2+), in the kidneys of the old blood-transfused guinea pigs suggests very high concentrations of ferric Hb can accumulate in renal tissues at 24 h after old blood transfusion. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Discussion

a(MESH:Mortality) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

After resuscitation with SRBCs, only 58% of mice survived for 48 hours (SRBC vs. FRBC, P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

p(HGNC:HBB) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Old blood transfusion resulted in systemic free Hb total exposure (AUC0–∞) of 4600 μmol heme-h/l, which was primarily cleared by the kidney within 24 h. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

p(HGNC:HBB) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

In old blood-transfused animals, strong Hb and iron deposition was observed in the tubule lumen and epithelial cells, respectively. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney Tubules
Text Location
Results

p(HGNC:HBB) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

In mice resuscitated with SRBCs, plasma hemoglobin levels were greater than in mice resuscitated with FRBCs or in sham-treated mice at two, four, and 24 hours after transfusion (Figure 1C). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hpx) negativeCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

In animals resuscitated with SRBCs, plasma hemopexin levels significantly decreased from 147.1±11.4 mg/dl at baseline to 86.7±12.2 and 76.3±5. 4 mg/dl at two and four hours after resuscitation, respectively (p<0.05 for both, Figure 2A). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Alb)) hasComponent a(MESH:"Blood Transfusion") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) hasComponent a(MESH:"Blood Transfusion") View Subject | View Object

Appears in Networks:

p(MGI:Hp) negativeCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

The increase in plasma haptoglobin levels from baseline to 48 hours after resuscitation was less in mice transfused with SRBCs compared to mice transfused with FRBCs (P<0.001). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) hasComponent a(MESH:"Blood Transfusion") View Subject | View Object

Appears in Networks:

p(MGI:Got1) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Liver damage, measured by plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST) at 48 hours after resuscitation, was greater after resuscitation with SRBCs compared to resuscitation with FRBCs (Figure 6E and F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Hemorrhage
Text Location
Results

p(MGI:Gpt) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Liver damage, measured by plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST) at 48 hours after resuscitation, was greater after resuscitation with SRBCs compared to resuscitation with FRBCs (Figure 6E and F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Hemorrhage
Text Location
Results

p(MGI:Havcr1) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Lcn2) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

p(MGI:Mki67) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Kidney sections of mice resuscitated with SRBCs showed more cortical Ki-67 positive cells per 20× field (1.08 mm field diameter) than those of mice resuscitated with FRBCs (SRBC vs. FRBC: 156.2±10.4 vs. 56.4±4.7, p<0.01). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemoglobinuria) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Isovolemic transfusion of guinea pigs with 10-unit equivalents of old blood, which consisted of red blood cells that were stored for 28 days, led to moderate hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

path(MESH:Hemoglobinuria) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Hemoglobinuria was noted in mice resuscitated with SRBCs alone but not mice resuscitated with FRBCs or sham-treated mice (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

The plasma hemoglobin levels at two and four hours after SRBC-transfusion were greater than the cell-free hemoglobin levels in the supernatant of the SRBCs before transfusion (Figure 1C, Supplemental Table I), providing evidence that hemolysis occurs in vivo during and after transfusion of SRBCs. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

path(MESH:Stroke) negativeCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
Text Location
Review

path(MESH:Thrombosis) association a(MESH:"Blood Transfusion") View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

r(MGI:Lcn2) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

Out-Edges 31

a(MESH:"Blood Transfusion") increases bp(MESH:"Platelet Activation") View Subject | View Object

In acute coronary syndrome, RBC transfusion increases platelet reactivity [31]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Acute Coronary Syndrome
Text Location
Review

a(MESH:"Blood Transfusion") increases path(MESH:Hemolysis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

a(MESH:"Blood Transfusion") increases path(MESH:Hemolysis) View Subject | View Object

Biochemical and biomechanical changes occur in the RBCs during the storage process, ultimately leading to increased haemolysis upon transfusion (Cohen & Matot, 2013). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Blood Transfusion") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

The plasma hemoglobin levels at two and four hours after SRBC-transfusion were greater than the cell-free hemoglobin levels in the supernatant of the SRBCs before transfusion (Figure 1C, Supplemental Table I), providing evidence that hemolysis occurs in vivo during and after transfusion of SRBCs. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") association path(MESH:Thrombosis) View Subject | View Object

Multiple haemolytic disorders and therapeutic interventions produce substantial intravascular haemolysis. Examples include PNH, SCD, thalassaemias, glucose-6-phosphate dehydrogenase (G6PD) deficiency, hereditary spherocytosis and stomatocytosis, pyruvate kinase deficiency, autoimmune haemolytic anaemia, microangiopathies, acute haemolytic transfusion reactions, mechanical circulatory support [e.g., left ventricular assist device (LVAD)/extracorporeal membrane oxygenation (ECMO)], RBC transfusions and infusions of RBC substitutes. These disorders, therapies and procedures are also associated with an increased risk of thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

a(MESH:"Blood Transfusion") negativeCorrelation path(MESH:Stroke) View Subject | View Object

Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
Text Location
Review

a(MESH:"Blood Transfusion") positiveCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Isovolemic transfusion of guinea pigs with 10-unit equivalents of old blood, which consisted of red blood cells that were stored for 28 days, led to moderate hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Hemoglobinuria was noted in mice resuscitated with SRBCs alone but not mice resuscitated with FRBCs or sham-treated mice (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Old blood transfusion resulted in systemic free Hb total exposure (AUC0–∞) of 4600 μmol heme-h/l, which was primarily cleared by the kidney within 24 h. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(HGNC:HBB) View Subject | View Object

In old blood-transfused animals, strong Hb and iron deposition was observed in the tubule lumen and epithelial cells, respectively. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney Tubules
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(HGNC:HBB) View Subject | View Object

In mice resuscitated with SRBCs, plasma hemoglobin levels were greater than in mice resuscitated with FRBCs or in sham-treated mice at two, four, and 24 hours after transfusion (Figure 1C). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") increases p(HGNC:HBB) View Subject | View Object

There is a clear need for, and medical benefit from, blood transfusions; nonetheless, administration of red blood cells (RBCs) does result in exposure to toxicants specific to hemoglobin (Hb) and its degradation components, hemin and iron. PubMed:30281034

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:methemoglobin) View Subject | View Object

Electron paramagnetic resonance (EPR) spectra of renal tissues from old blood-transfused animals were recorded at 6K and showed a strong signal around g=6, which is indicative of high-spin ferric Hb(Fe3+) (Figure 3a). PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:methemoglobin) View Subject | View Object

First, quantification of high-spin ferric Hb(Fe3+), which is the initial Hb oxidation product resulting from the oxidation of ferrous oxyHb(Fe2+), in the kidneys of the old blood-transfused guinea pigs suggests very high concentrations of ferric Hb can accumulate in renal tissues at 24 h after old blood transfusion. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Discussion

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

In old blood-transfused animals, strong Hb and iron deposition was observed in the tubule lumen and epithelial cells, respectively. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney Tubules
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Tissue iron staining revealed greater cortical iron accumulation in the kidneys of mice resuscitated with SRBCs, SRBCs combined with albumin and SRBCs combined with hemopexin than in the kidneys of mice transfused with FRBCs (Figure 6A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") increases a(CHEBI:heme) View Subject | View Object

There is a clear need for, and medical benefit from, blood transfusions; nonetheless, administration of red blood cells (RBCs) does result in exposure to toxicants specific to hemoglobin (Hb) and its degradation components, hemin and iron. PubMed:30281034

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Splenic iron content was greater in mice after resuscitation with SRBCs than in FRBC-transfused mice. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Taken together, these results indicate that haptoglobin co-transfusion prevented stored blood transfusion-associated renal iron uptake and led to increased weight and greater iron- accumulation in the spleens of mice. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") increases a(CHEBI:"iron(2+)") View Subject | View Object

There is a clear need for, and medical benefit from, blood transfusions; nonetheless, administration of red blood cells (RBCs) does result in exposure to toxicants specific to hemoglobin (Hb) and its degradation components, hemin and iron. PubMed:30281034

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"Blood Transfusion") positiveCorrelation a(CHEBI:"4-hydroxynon-2-enal") View Subject | View Object

Renal tissues from old blood-transfused animals exhibited 4-HNE-positive staining. PubMed:26794659

Appears in Networks:
Annotations
Cell Ontology (CL)
epithelial cell
MeSH
Kidney
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation a(MESH:Mortality) View Subject | View Object

After resuscitation with SRBCs, only 58% of mice survived for 48 hours (SRBC vs. FRBC, P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") negativeCorrelation p(MGI:Hpx) View Subject | View Object

In animals resuscitated with SRBCs, plasma hemopexin levels significantly decreased from 147.1±11.4 mg/dl at baseline to 86.7±12.2 and 76.3±5. 4 mg/dl at two and four hours after resuscitation, respectively (p<0.05 for both, Figure 2A). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") negativeCorrelation p(MGI:Hp) View Subject | View Object

The increase in plasma haptoglobin levels from baseline to 48 hours after resuscitation was less in mice transfused with SRBCs compared to mice transfused with FRBCs (P<0.001). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(MGI:Havcr1) View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation r(MGI:Lcn2) View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(MGI:Lcn2) View Subject | View Object

Markers of renal damage, including kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels, and plasma NGAL concentration, were greater in mice after resuscitation with SRBCs or SRBCs and albumin than in mice transfused with FRBCs (Figures 4C–F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(MGI:Mki67) View Subject | View Object

Kidney sections of mice resuscitated with SRBCs showed more cortical Ki-67 positive cells per 20× field (1.08 mm field diameter) than those of mice resuscitated with FRBCs (SRBC vs. FRBC: 156.2±10.4 vs. 56.4±4.7, p<0.01). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(MGI:Gpt) View Subject | View Object

Liver damage, measured by plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST) at 48 hours after resuscitation, was greater after resuscitation with SRBCs compared to resuscitation with FRBCs (Figure 6E and F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation p(MGI:Got1) View Subject | View Object

Liver damage, measured by plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST) at 48 hours after resuscitation, was greater after resuscitation with SRBCs compared to resuscitation with FRBCs (Figure 6E and F). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Hemorrhage
Text Location
Results

a(MESH:"Blood Transfusion") decreases p(HGNC:HP) View Subject | View Object

In diseases of intravascular hemolysis, Hp is often not detectable and lower Hp levels are associated with transfusion. PubMed:30281034

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

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