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a(HM:Immunothrombosis)

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Entity

Name
Immunothrombosis
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

bp(MESH:"Erythrocyte Aggregation") positiveCorrelation a(HM:Immunothrombosis) View Subject | View Object

Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Introduction

bp(MESH:"Platelet Activation") positiveCorrelation a(HM:Immunothrombosis) View Subject | View Object

The cascade of immunothrombosis includes platelet activation and secretion, which may result in a local increase in Zn2þ concentration because of the presence of Zn2þ in platelet dense granules. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

p(MGI:Hrg) decreases a(HM:Immunothrombosis) View Subject | View Object

Supplementary treatment of septic mice with purified HRG from human plasma remarkably suppressed immunothrombosis in the lungs as well as the associated inflammation. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Lung
MeSH
Sepsis
Text Location
Discussion

Out-Edges 2

a(HM:Immunothrombosis) positiveCorrelation bp(MESH:"Erythrocyte Aggregation") View Subject | View Object

Although neutrophils, platelets and vascular endothelial cells are the main effector cells involved in immunothrombosis, abnormal aggregation of erythrocytes under septic conditions may also contribute to immunothrombosis in sepsis. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Introduction

a(HM:Immunothrombosis) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

The cascade of immunothrombosis includes platelet activation and secretion, which may result in a local increase in Zn2þ concentration because of the presence of Zn2þ in platelet dense granules. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.