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path(MESH:Necrosis)

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Entity

Name
Necrosis
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) View Subject | View Object

NFT containing neurons upregulated genes involved in cell survival and viability, inflammation, cell cycle progression and molecular transport and downregulated apoptosis, necrosis and cell death pathways (Figure 1a). NFkB, a pro-survival master transcriptional regulator of inflammation, was the highest predicted upstream regulator of the NFT-gene expression profile. In agreement with inflammatory activation, other predicted upstream regulators included IFNG, TNF, TLR4, IL1B and CXCL1 (Figure 1b) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis) View Subject | View Object

Cataclysmic disruption of lysosomal membranes releases hydrolases that act as both the trigger and executioner in rapid necrosis (Syntichaki et al. 2003; Kroemer et al. 2005), whereas slow release of cathepsins more likely operates through signaling pathways to trigger apoptosis (Kroemer et al. 2005). PubMed:22908190

Appears in Networks:

p(HGNC:AMBP) negativeCorrelation path(MESH:Necrosis) View Subject | View Object

Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
Text Location
Results

Out-Edges 1

path(MESH:Necrosis) negativeCorrelation p(HGNC:AMBP) View Subject | View Object

Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
Text Location
Results

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.